Persons with first episode psychosis have distinct profiles of social cognition and metacognition
Ferrer-Quintero, Marta (Centro de Investigación Biomédica en Red de Salud Mental)
López-Carrilero, R. (Fundació Sant Joan de Déu per a la Recerca)
Birulés, Irene (Universitat de Barcelona)
Barajas Vélez, Ana (Associació Centre Higiene Mental Les Corts (Barcelona, Catalunya))
Lorente-Rovira, E. (Hospital Clínic Universitari (València))
Díaz-Cutraro, L. (Parc Sanitari Sant Joan de Déu)
Verdaguer, M. (Parc Sanitari Sant Joan de Déu)
García-Mieres, H. (Parc Sanitari Sant Joan de Déu)
Sevilla-Llewellyn-Jones, J. (Hospital Clínico San Carlos (Madrid))
Gutiérrez-Zotes, Alfonso (Institut Pere Mata, Reus)
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau)
Pousa, Esther (Institut Hospital del Mar d'Investigacions Mèdiques)
Huerta-Ramos, Elena (Centro de Investigación Biomédica en Red de Salud Mental)
Pélaez, T. (Centro de Investigación Biomédica en Red de Salud Mental)
Barrigón, María Luisa (Area de Gestión Sanitaria Sur Granada, Motril)
González-Higueras, Fermín (Complejo Hospitalario de Jaén)
Ruiz-Delgado, I. (Unidad de Salud Mental Comunitaria Málaga Norte)
Cid Colom, Jordi (Institut d'Assistencia Sanitària, Girona)
Moritz, Steffen (University Medical Center Hamburg)
Ochoa, Susana (Centro de Investigación Biomédica en Red de Salud Mental)
Fernández, Daniel (Universitat Politècnica de Catalunya)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Subjects with first-episode psychosis experience substantial deficits in social cognition and metacognition. Although previous studies have investigated the role of profiles of individuals in social cognition and metacognition in chronic schizophrenia, profiling subjects with first-episode psychosis in both domains remains to be investigated. We used latent profile analysis to derive profiles of the abilities in 174 persons with first-episode psychosis using the Beck's Cognitive Insight Scale, the Faces Test, the Hinting Task, the Internal, Personal and Situational Attributions Questionnaire, and the Beads Task. Participants received a clinical assessment and a neuropsychological assessment. The best-fitting model was selected according to the Bayesian information criterion (BIC). We assessed the importance of the variables via a classification tree (CART). We derived three clusters with distinct profiles. The first profile (33. 3%) comprised individuals with low social cognition. The second profile (60. 9%) comprised individuals that had more proneness to present jumping to conclusions. The third profile (5. 7%) presented a heterogeneous profile of metacognitive deficits. Persons with lower social cognition presented worse clinical and neuropsychological features than cluster 2 and cluster 3. Cluster 3 presented significantly worst functioning. Our results suggest that individuals with FEP present distinct profiles that concur with specific clinical, neuropsychological, and functional challenges. Each subgroup may benefit from different interventions.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-622 Ministerio de Ciencia e Innovación RTI2018-100927-J-I00
Note:	Altres ajuts: Obra Social La Caixa (RecerCaixa call 2013), by the Agencia Estatal de Investigación (AEI, Spain). Junta de Andalucía: PI-0634/2011; PI-0193/2014.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Health sciences ; Psychosis ; Schizophrenia
Published in:	NPJ Schizophrenia, Vol. 7 (december 2021) , ISSN 2334-265X

Erratum: https://ddd.uab.cat/record/258974
DOI: 10.1038/s41537-021-00187-8
PMID: 34887442

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles