Fujifilm silvamp tb-lam for the diagnosis of tuberculosis in nigerian adults
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol)
Bimba, John (Bingham University. Zankli Research Centre and Department of Community Medicine)
Adelakun, Ramota (Liverpool School of Tropical Medicine. Department of Clinical Sciences)
Kontogianni, Konstantina (Liverpool School of Tropical Medicine. Department of Clinical Sciences)
Molina-Moya, Barbara (Institut Germans Trias i Pujol)
Osazuwa, Okoedoh (Bingham University. Zankli Research Centre and Department of Community Medicine)
Creswell, Jacob (TB REACH. Stop TB Partnership)
Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences.)
Domínguez, José (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

Data:	2021
Resum:	There is a need for diagnostics for tuberculosis (TB) that are easy to use, able to screen non-sputum samples, and able to provide rapid results for the management of both immunocompromised and immunocompetent individuals. The Fujifilm SILVAMP TB LAM (FujiLAM) assay, a new non-sputum based point of need test for the diagnosis of TB, could potentially address most of these needs. We evaluated the performance of FujiLAM in HIV positive and HIV negative patients with presumptive TB attending three district hospitals in Nigeria. Consecutive patients were asked to provide urine samples on the spot, which were tested with FujiLAM. The results were compared against a positive culture and/or Xpert MTB/RIF as the reference standard. Forty-five patients had bacteriologically confirmed TB, and 159 had negative culture and Xpert MTB/RIF (no TB). The FujiLAM test was positive in 23 (sensitivity 65. 7%, 95% CI = 48-80) HIV negative and seven (70%, 95% CI = 35-92) HIV positive patients with bacteriological confirmation of TB. FujiLAM was negative in 97 (specificity 99. 0%, 95% CI = 94-100) HIV negative and 56 (93. 3%, 95% CI = 83-98) HIV positive patients without TB. The FujiLAM test has good diagnostic accuracy for considering its application in both HIV positive and HIV negative patients with TB.
Ajuts:	Instituto de Salud Carlos III DTS18/0092 Instituto de Salud Carlos III FIS19/01408 European Commission 823854
Nota:	Altres ajuts: EDCTP grant number DRIA2014-309; TB REACH award grant number CA-3-D000920001
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Tuberculosis ; Diagnosis ; Lipoarabinomannan ; LAM ; HIV ; Urine ; Point-of-care
Publicat a:	Journal of clinical medicine, Vol. 10 Núm. 11 (june 2021) , p. 2514, ISSN 2077-0383

DOI: 10.3390/jcm10112514
PMID: 34204120

9 p, 376.9 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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