Influence of Olive Oil and Its Components on Breast Cancer : Molecular Mechanisms
Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Escrich, Eduard (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Data:	2022
Resum:	Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as a healthy dietary pattern with protective effects in several chronic diseases, including breast cancer. This diet is characterized by the consumption of abundant plant foods and olive oil as the principal source of fat, which is considered one of the main components with potential antioxidant, anti-inflammatory and anticancer effects. Extra-virgin olive oil (EVOO) has several bioactive compounds, mainly including monounsaturated fatty acids, triterpenes and polyphenols, such as phenolic alcohols (e. g. , hydroxytyrosol), secoiridoids (e. g. , oleuropein and oleocanthal), lignans (e. g. , pinoresinol) or flavonoids (e. g. , luteolin). While epidemiological evidence is still limited, experimental in vivo and in vitro data have shown a protective effect of this oil and its compounds on mammary carcinogenesis. Such effects account through complex and multiple mechanisms, including changes in epigenetics, transcriptome and protein expression that modulate several signaling pathways. Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks. Although further research is needed to elucidate their beneficial effects on human prevention and progression of the disease, evidence points to EVOO in the context of the Mediterranean diet as a heathy choice, while EVOO components may be promising adjuvants in anticancer strategies.
Ajuts:	Ministerio de Educación y Ciencia AGL2006-07691 Generalitat de Catalunya GC2010-165.000
Nota:	Altres ajuts: Fundación Patrimonio Comunal Olivarero (FPCO): FPCO2008-165.396, FPCO2013-CF611.084; Agencia para el Aceite de Oliva del Ministerio de Agricultura, Alimentación y Medio Ambiente: AAO2008-165.471; Organización Interprofesional del Aceite de Oliva Español (OIAOE): OIP2009-CD165.646
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Olive oil ; EVOO ; Breast cancer ; Minor compounds ; Apoptosis ; Proliferation ; Migration
Publicat a:	Molecules, Vol. 27 Num. 2 (january 2022) , ISSN 1420-3049

DOI: 10.3390/molecules27020477
PMID: 35056792

38 p, 2.3 MB

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