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| Pàgina inicial > Articles > Articles publicats > Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
(Universitat Autònoma de Barcelona. Departament de Medicina) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universitat Rovira i Virgili) (Institut d'Investigació Biomèdica Sant Pau) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut d'Investigació Biomèdica Sant Pau) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universitat de Lleida) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)| Data: | 2021 |
| Resum: | Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4. 1 (0-8) years. CV death occurred in 120 (30. 5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8. 39 nm vs. 8. 31 nm, p < 0. 001). This change in size was due to a reduction in the percentage of small HDL-P (54. 6% vs. 60% for CV-death vs. alive; p < 0. 001). HDL-C/P ratio was higher in the CV-death group (51. 0 vs. 48. 3, p < 0. 001). HDL-Sz and HDL-C/P ratio were significantly associated with CV death after multivariable regression analysis (HR 1. 22 [95% CI 1. 01-1. 47], p = 0. 041 and HR 1. 04 [95% CI 1. 01-1. 07], p = 0. 008 respectively). HDL-Sz and HDL-C/P ratio are independent predictors of CV death in chronic HF patients. |
| Ajuts: | Ministerio de Economía, Industria y Competitividad PI17-00232 Ministerio de Economía, Industria y Competitividad PI17-01362 Instituto de Salud Carlos III RED2018-102799-T Instituto de Salud Carlos III PI15-00625 Instituto de Salud Carlos III PI17-00232 Instituto de Salud Carlos III PI17-01362 Instituto de Salud Carlos III CB16/11/00403 Instituto de Salud Carlos III CB15/00071 Instituto de Salud Carlos III CB07/08/0016 Instituto de Salud Carlos III CPII18/00004 Instituto de Salud Carlos III CB15/00071 Ministerio de Educación, Cultura y Deporte SAF2014-59892 |
| Nota: | Altres ajuts: Fundació la Marató de TV3: 201602-30-31; 201502 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Biomarkers ; Prognostic markers ; Heart failure |
| Publicat a: | Scientific reports, Vol. 11 (february 2021) , ISSN 2045-2322 |
