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Pàgina inicial > Articles > Articles publicats > Sex differences in the behavioral variant of frontotemporal dementia : |
Data: | 2021 |
Resum: | Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown. We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical characteristics and cortical thickness between men and women with bvFTD and controls. We followed the residuals approach to study behavioral and cognitive reserve. At diagnosis, women with bvFTD showed greater atrophy burden in the frontotemporal regions compared to men despite similar clinical characteristics. For a similar amount of atrophy, women demonstrated better-than-expected scores on executive function and fewer changes in apathy, sleep, and appetite than men. Our findings suggest that women might have greater behavioral and executive reserve than men, and neurodegeneration must be more severe in women to produce symptoms similar in severity to those in men. |
Ajuts: | Instituto de Salud Carlos III PI14/01126 Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI13/01532 Instituto de Salud Carlos III PI16/01825 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI15/01618 Instituto de Salud Carlos III PI14/1561 Instituto de Salud Carlos III PI18/00326 Instituto de Salud Carlos III AC14/00013 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III CM17/00074 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-0235 |
Nota: | Altres ajuts: the "Marató TV3" grant (20141210 to JF, 044412 to RB, and 20143810 to RS-V), by Generalitat de Catalunya (PERIS SLT002/16/00408, PERIS SLT006/17/125 to DA, and SLT006/17/00119 to JF) |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Cognitive reserve ; Diagnosis ; Frontotemporal dementia ; Magnetic resonance imaging ; Neuroimaging ; Progression ; Resilience ; Survival |
Publicat a: | Alzheimer's & Dementia, Vol. 17 (february 2021) , p. 1329-1341, ISSN 1552-5279 |
13 p, 2.1 MB |