Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma
Cubillos-Zapata, Carolina (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Martínez-García, Miguel Ángel (Hospital Universitari i Politècnic La Fe (València))
Díaz-García, Elena (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Jaureguizar, Ana (Instituto de Investigación Sanitaria del Hospital Universitario La Paz)
Campos-Rodríguez, Francisco (Instituto de Biomedicina de Sevilla)
Sánchez-de-la-Torre, Manuel (Institut de Recerca Biomèdica de Lleida)
Nagore, Eduardo (Instituto Valenciano Oncologia)
Martorell-Calatayud, Antonio (Hospital de Manises (València))
Blasco, Luis Hernández (Universidad Miguel Hernández de Elche)
Pastor, Esther (Hospital Universitario San Juan de Alicante)
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Montserrat, Josep María (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Cabriada-Nuño, Valentín (Hospital Universitario de Cruces (Barakaldo, País Basc))
Cano-Pumarega, Irene (Hospital Universitario Ramón y Cajal (Madrid))
Corral-Peñafiel, Jaime (Hospital San Pedro de Alcántara)
Arias, Eva (Hospital Universitario 12 de Octubre (Madrid))
Mediano, Olga (Hospital Universitario de Guadalajara)
Somoza-González, María (Consorci Sanitari de Terrassa)
Dalmau-Arias, Joan (Institut d'Investigació Biomèdica Sant Pau)
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
López-Collazo, Eduardo (Instituto de Investigación Sanitaria del Hospital Universitario La Paz)
Gozal, David (University of Missouri School of Medicine)
García-Rio, Francisco (Universidad Autónoma de Madrid)
Universitat Autònoma de Barcelona
Date: |
2020 |
Abstract: |
Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in patients with cutaneous melanoma (CM), assess their relationship with melanoma aggressiveness and analyze the factors related to TGF-β1 levels in obese and non-obese OSA patients. In a multicenter observational study, 290 patients with CM were underwent sleep studies. TGF-β1 was increased in moderate-severe OSA patients vs. non-OSA or mild OSA patients with CM. In OSA patients, TGF-β1 levels correlated with mitotic index, Breslow index and melanoma growth rate, and were increased in presence of ulceration or higher Clark levels. In CM patients, OSA was associated with higher TGF-β1 levels and greater melanoma aggressiveness only in non-obese subjects. An in vitro model showed that IH-induced increases of TGF-β1 expression in melanoma cells is attenuated in the presence of high leptin levels. In conclusion, TGF-β1 levels are associated with melanoma aggressiveness in CM patients and increased in moderate-severe OSA. Moreover, in non-obese patients with OSA, TGF-β1 levels correlate with OSA severity and leptin levels, whereas only associate with leptin levels in obese OSA patients. |
Grants: |
Instituto de Salud Carlos III PI19/01363 Instituto de Salud Carlos III PI16/01772 Instituto de Salud Carlos III PIE15/00065 Instituto de Salud Carlos III PI16/00201
|
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Cancer ;
Diseases ;
Medical research ;
Oncology ;
Pathogenesis |
Published in: |
Scientific reports, Vol. 10 (september 2020) , ISSN 2045-2322 |
DOI: 10.1038/s41598-020-72481-x
PMID: 32968152
The record appears in these collections:
Research literature >
UAB research groups literature >
Research Centres and Groups (research output) >
Health sciences and biosciences >
Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)Research literature >
UAB research groups literature >
Research Centres and Groups (research output) >
Health sciences and biosciences >
Institut de Recerca Sant PauArticles >
Research articlesArticles >
Published articles
Record created 2022-02-07, last modified 2024-05-02