Therapy-Induced Modulation of the Tumor Microenvironment : New Opportunities for Cancer Therapies
Benavente, Sergi (Vall d'Hebron Institut d'Oncologia)
Sánchez-García, Almudena (Hospital Universitari Vall d'Hebron)
Naches Solsona, Silvia (Hospital Universitari Vall d'Hebron)
LLeonart, Matilde Esther (Centro de Investigación Biomédica en Red de Cáncer)
Lorente, Juan (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. At the same time, the clinical successes achieved with minimally invasive and optically-guided surgery and image-guided and ablative radiation strategies have been successfully implemented in clinical care. More effective, localized and safer treatments have fueled strong research interest in radioimmunotherapy, which has shown the potential immunomodulatory effects of ionizing radiation. However, increasingly more observations suggest that immunosuppressive changes, metabolic remodeling, and angiogenic responses in the local tumor microenvironment play a central role in tumor recurrence. In this review, we address challenges to identify responders vs. non-responders to the immune checkpoint blockade, discuss recent developments in combinations of immunotherapy and radiotherapy for clinical evaluation, and consider the clinical impact of immunosuppressive changes in the tumor microenvironment in the context of surgery and radiation. Since the therapy-induced modulation of the tumor microenvironment presents a multiplicity of forms, we propose that overcoming microenvironment related resistance can become clinically relevant and represents a novel strategy to optimize treatment immunogenicity and improve patient outcome.
Ajuts:	Ministerio de Economía y Competitividad CP03/00101 Ministerio de Economía y Competitividad PI15/01262
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Radiotherapy ; Immunotherapy ; Tumor microenvironment ; Surgery ; Cancer
Publicat a:	Frontiers in Oncology, Vol. 10 (october 2020) , ISSN 2234-943X

DOI: 10.3389/fonc.2020.582884
PMID: 33194719

18 p, 2.3 MB

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