Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization
Fuchs, Anke (Technische Universität Dresden, Germany)
Gliwiński, Mateusz (Medical University of Gdańsk, Poland)
Grageda, Nathali (MRC Centre for Transplantation, King's College London, Guy's Hospital)
Spiering, Rachel (Newcastle University)
Abbas, Abul K. (University of California, San Francisco)
Appel, Silke (University of Bergen, Norway)
Bacchetta, Rosa (Stanford School of Medicine, United States)
Battaglia, Manuela (San Raffaele Hospital, Milan)
Berglund, David (Uppsala University, Sweden)
Blazar, Bruce (University of Minnesota, United States)
Bluestone, Jeffrey A. (University of California, San Francisco, United States)
Bornhäuser, Martin (Technische Universität Dresden, Germany)
ten Brinke, Anja (University of Amsterdam)
Brusko, Todd M. (University of Florida Diabetes Institute)
Cools, Nathalie (University Hospital Antwerp (Bèlgica))
Cuturi, Maria Cristina (Université de Nantes)
Geissler, Edward (University Hospital Regensburg, Germany)
Giannoukakis, Nick (Carnegie Mellon University, Pittsburgh, United States)
Gołab, Karolina (The University of Chicago, United States)
Hafler, David A. (Yale School of Medicine, New Haven, United States)
van Ham, S. Marieke (University of Amsterdam)
Hester, Joanna (University of Oxford)
Hippen, Keli (University of Minnesota, United States)
Di Ianni, Mauro (University of Chieti-Pescara)
Ilic, Natasa (University of Belgrade)
Isaacs, John (National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University)
Issa, Fadi (University of Oxford)
Iwaszkiewicz-Grzes, Dorota (Medical University of Gdańsk, Poland)
Jaeckel, Elmar (Department of Gastroenterology, Hepatology, Endocrinology, Diabetology, Transplantationsforschungszentrum, Medical School of Hannover (MHH))
Joosten, Irma (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands)
Klatzmann, David (Hôpital Pitié-Salpêtrière, Paris)
Koenen, Hans (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands)
van Kooten, Cees (Leiden University Medical Center, Netherlands)
Korsgren, Olle (Gothenburg University, Sweden)
Kretschmer, Karsten (University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Germany)
Levings, Megan (The University of British Columbia, Vancouver, Canada)
Marek-Trzonkowska, Natalia Maria (Medical University of Gdańsk, Poland)
Martinez-Llordella, Marc (King's College London)
Miljkovic, Djordje (University of Belgrade)
Mills, Kingston H. G. (Trinity College Dublin, Ireland)
Miranda, Joana P. (Universidade de Lisboa)
Piccirillo, Ciriaco A. (Research Institute of McGill University Health Centre, Montréal, Canada)
Putnam, Amy L. (University of California, San Francisco)
Ritter, Thomas (National University of Ireland)
Roncarolo, Maria Grazia (Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine)
Sakaguchi, Shimon (Osaka University, Japan)
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid))
Sawitzki, Birgit (Humboldt-Universität zu Berlin)
Sofronic-Milosavljevic, Ljiljana (University of Belgrade)
Sykes, Megan (University of California, San Francisco)
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Waldmann, Herman (University of Oxford)
Witkowski, Piotr (The University of Chicago)
Wood, Kathryn J. (University of Oxford)
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute IRCCS)
Hilkens, Catharien M. U. (Newcastle University)
Lombardi, Giovanna (MRC Centre for Transplantation, King's College London, Guy's Hospital)
Lord, Phillip (School of Computing, Newcastle University)
Martinez-Caceres, Eva Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Trzonkowski, Piotr (Medical University of Gdańsk, Poland)

Data:	2018
Resum:	Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Minimum information model ; T regulatory cells ; Immunotherapy ; Good manufacturing practice ; Cell therapy ; Immune tolerance
Publicat a:	Frontiers in immunology, Vol. 8 (january 2018) , ISSN 1664-3224

DOI: 10.3389/fimmu.2017.01844
PMID: 29379498

15 p, 4.5 MB

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