Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma
Toptan, Tuna (University of Pittsburgh, Pennsylvania, United States of America)
Brusadelli, Marion G. (Cincinnati Children's Hospital Medical Center)
Turpin, Brian (Cincinnati Children's Hospital Medical Center)
Witte, David P. (Cincinnati Children's Hospital Medical Center)
Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Velleuer, Eunike (Hospital Neuwerk Maria von den Aposteln, Mönchengladbach, Germany)
Schramm, Martin (Heinrich Heine University, Düsseldorf, Germany)
Dietrich, Ralf (Deutsche Fanconi-Anämie-Hilfe e.V., Unna-Siddinghausen, Germany)
Brakenhoff, Ruud H. (Vrije Universiteit Amsterdam, The Netherlands)
Moore, Patrick S. (University of Pittsburgh, Pennsylvania, United States of America)
Chang, Yuan (University of Pittsburgh, Pennsylvania, United States of America)
Wells, Susanne I. (Cincinnati Children's Hospital Medical Center)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 13 (december 2018) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0209235
PMID: 30589865

9 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles