Multiple adverse drug reactions and genetic polymorphism testing
Arellano, Ana Lucía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Martin-Subero, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Monerris, Mar (Universitat Autònoma de Barcelona. Departament de Cirurgia)
LLerena, Adrián (CICAB Clinical Research Center, Extremadura University Hospital and Medical School)
Farré Albaladejo, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Montané Esteva, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Date:	2017
Abstract:	Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period. A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency. Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adverse drug reactions ; CYP2D6 ; Drug metabolism ; Genetic polymorphism ; Multiple drug intolerance syndrome
Published in:	Medicine, Vol. 96 (november 2017) , ISSN 1536-5964

DOI: 10.1097/MD.0000000000008505
PMID: 29137046

3 p, 168.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles