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| Pàgina inicial > Articles > Articles publicats > Lactate and the Lactate-to-Pyruvate Molar Ratio Cannot Be Used as Independent Biomarkers for Monitoring Brain Energetic Metabolism : |
(Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron)| Data: | 2014 |
| Resum: | For decades, lactate has been considered an excellent biomarker for oxygen limitation and therefore of organ ischemia. The aim of the present study was to evaluate the frequency of increased brain lactate levels and the LP ratio (LPR) in a cohort of patients with severe or moderate traumatic brain injury (TBI) subjected to brain microdialysis monitoring to analyze the agreement between these two biomarkers and to indicate brain energy metabolism dysfunction. Forty-six patients with an admission Glasgow coma scale score of ≤13 after resuscitation admitted to a dedicated 10-bed Neurotraumatology Intensive Care Unit were included, and 5305 verified samples of good microdialysis data were analyzed. Lactate levels were above 2. 5 mmol/L in 56. 9% of the samples. The relationships between lactate and the LPR could not be adequately modeled by any linear or non-linear model. Neither Cohen's kappa nor Gwet's statistic showed an acceptable agreement between both biomarkers to classify the samples in regard to normal or abnormal metabolism. The dataset was divided into four patterns defined by the lactate concentrations and the LPR. A potential interpretation for these patterns is suggested and discussed. Pattern 4 (low pyruvate levels) was found in 10. 7% of the samples and was characterized by a significantly low concentration of brain glucose compared with the other groups. Our study shows that metabolic abnormalities are frequent in the macroscopically normal brain in patients with traumatic brain injuries and a very poor agreement between lactate and the LPR when classifying metabolism. The concentration of lactate in the dialysates must be interpreted while taking into consideration the LPR to distinguish between anaerobic metabolism and aerobic hyperglycolysis. |
| Ajuts: | Instituto de Salud Carlos III PI10/00302 Ministerio de Ciencia e Innovación PI11/00700 Ministerio de Economía y Competitividad PI12/00074 Ministerio de Ciencia e Innovación FI11/00195 |
| Nota: | Altres ajuts: This study has been supported by the Fondo de Investigación Sanitaria (Instituto de Salud Carlos III-) with grants PI10/00302 and PI11/00700, which were co-financed by the European Regional Development Fund and awarded to MP and JS, respectively. This work has also been partially supported by the Fundación Mutua Madrileña () with grant FMM-2010-10 given to JS. AS and TM are the recipients of two pre-doctoral grants from the Instituto de Salud Carlos III (grants number FI12/00074 and FI11/00195, respectively). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Publicat a: | PloS one, Vol. 9 (july 2014) , ISSN 1932-6203 |
