Detection of resistance mutations and CD4 slopes in individuals experiencing sustained virological failure
Schultze, Anna (Department of Infection and Population Health, University College London, UK)
Paredes, Roger (IrsiCaixa)
Sabin, Caroline A. (Department of Infection and Population Health, University College London, UK)
Phillips, Andrew N. (Department of Infection and Population Health, University College London, UK)
Pillay, Deenan (Department of Infection and Population Health, University College London, UK)
Kirk, Ole (Copenhagen University Hospital Rigshospitalet, Denmark)
Lundgren, Jens (Copenhagen University Hospital Rigshospitalet, Denmark)
Pozniak, Anton (HIV and Sexual Health - Kobler Clinic, Chelsea and Westminster Hospital, London, UK)
Nelson, Mark (HIV and Sexual Health - Kobler Clinic, Chelsea and Westminster Hospital, London, UK)
Cozzi-Lepri, Alessandro (University College London, UK)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2014
Abstract:	Several resistance mutations have been shown to affect viral fitness, and the presence of certain mutations might result in clinical benefit for patients kept on a virologically failing regimen due to an exhaustion of drug options. We sought to quantify the effect of resistance mutations on CD4 slopes in patients undergoing episodes of viral failure. Patients from the EuroSIDA and UK CHIC cohorts undergoing at least one episode of virological failure (.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of the International AIDS Society, Vol. 17 (november 2014) , ISSN 1758-2652

DOI: 10.7448/IAS.17.4.19737
PMID: 25397482

1 p, 76.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles