Lower Locus Coeruleus MRI intensity in patients with late-life major depression
Guinea-Izquierdo, Andrés (Hospital Universitari de Bellvitge)
Giménez, Mónica (Hospital Universitari de Bellvitge)
Martínez-Zalacaín, Ignacio (Hospital Universitari de Bellvitge)
del Cerro, Inés (Hospital Universitari de Bellvitge)
Canal-Noguer, Pol (Universitat Politècnica de Catalunya)
Blasco, Gerard (Hospital Universitari de Bellvitge)
Gascón, Jordi (Hospital Universitari de Bellvitge)
Reñé, Ramon (Hospital Universitari de Bellvitge)
Rico, Inmaculada (Hospital Universitari de Bellvitge)
Camins, Angels (Hospital Universitari de Bellvitge)
Aguilera, Carlos (Hospital Universitari de Bellvitge)
Urretavizcaya, Mikel (Hospital Universitari de Bellvitge)
Ferrer, Isidro (Hospital Universitari de Bellvitge)
Menchón Magriñá, José Manuel (Hospital Universitari de Bellvitge)
Soria, Virginia (Hospital Universitari de Bellvitge)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)

Data:	2021
Resum:	The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. The characterization of such alterations may therefore help to predict progression to neurodegenerative disorders. Despite the LC cannot be visualized with conventional magnetic resonance imaging (MRI), specific MRI sequences have been developed to infer its structural integrity. We quantified LC signal Contrast Ratios (LCCRs) in late-life major depressive disorder (MDD) (n = 37, 9 with comorbid aMCI), amnestic Mild Cognitive Impairment (aMCI) (n = 21, without comorbid MDD), and healthy controls (HCs) (n = 31), and also assessed the putative modulatory effects of comorbidities and other clinical variables. LCCRs were lower in MDD compared to aMCI and HCs. While no effects of aMCI comorbidity were observed, lower LCCRs were specifically observed in patients taking serotonin/norepinephrine reuptake inhibitors (SNRIs). Our results do not support the hypothesis that lower LCCRs characterize the different clinical groups that may eventually develop a neurodegenerative disorder. Conversely, our results were specifically observed in patients with late-life MDD taking SNRIs. Further research with larger samples is warranted to ascertain whether medication or particular clinical features of patients taking SNRIs are associated with changes in LC neurons.
Ajuts:	Ministerio de Economía y Competitividad PIE14/00034 Ministerio de Educación, Cultura y Deporte FPU14/04822 Ministerio de Economía y Competitividad CPII16/00048
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Major depressive disorder ; Amnestic mild cognitive impairment ; Locus coeruleus ; Magnetic resonance imaging ; Neuromelanin ; Serotonin/norepinephrine reuptake inhibitors
Publicat a:	PeerJ, Vol. 9 (february 2021) , ISSN 2167-8359

DOI: 10.7717/peerj.10828
PMID: 33628639

22 p, 2.2 MB

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