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Pàgina inicial > Articles > Articles publicats > Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients |
Data: | 2021 |
Resum: | Background: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. Methods: We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Results: Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3. 1 (1. 4) and mean (SD) log HCV RNA was 6. 1 (0. 8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): −0. 04 (−0. 34, 0. 26), p = 0. 79)]. There was no significant association between any heavy drinking day and HCV RNA level (0. 07, 95% CI: (−0. 24, 0. 38), p = 0. 66). Conclusions: We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients. |
Ajuts: | Ministerio de Economía y Competitividad PI17/00174 Ministerio de Economía y Competitividad RD16/0017/0003 Generalitat de Catalunya 2017SGR316 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | HIV ; Chronic HCV infection ; HCV RNA levels ; Alcohol use disorder ; Unhealthy alcohol use ; Alcohol |
Publicat a: | Viruses, Vol. 13 (april 2021) , ISSN 1999-4915 |
9 p, 464.3 KB |