Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Nunes, David (Boston University School of Medicine)
Cheng, Debbie (Boston University School of Medicine)
Saitz, Richard (Boston University School of Medicine)
Samet, Jeffrey H. (Boston University School of Medicine)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Background: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. Methods: We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Results: Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3. 1 (1. 4) and mean (SD) log HCV RNA was 6. 1 (0. 8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): -0. 04 (-0. 34, 0. 26), p = 0. 79)]. There was no significant association between any heavy drinking day and HCV RNA level (0. 07, 95% CI: (-0. 24, 0. 38), p = 0. 66). Conclusions: We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients.
Ajuts:	Instituto de Salud Carlos III PI17/00174 Ministerio de Economía y Competitividad RD16/0017/0003 Generalitat de Catalunya 2017SGR316
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	HIV ; Chronic HCV infection ; HCV RNA levels ; Alcohol use disorder ; Unhealthy alcohol use ; Alcohol
Publicat a:	Viruses, Vol. 13 (april 2021) , ISSN 1999-4915

DOI: 10.3390/v13050716
PMID: 33919027

9 p, 464.3 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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