Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol)
Molina-Moya, Barbara (Institut Germans Trias i Pujol)
Gautier, Jacqueline (Hôpital Saint-Damien)
Villar-Hernández, Raquel (Institut Germans Trias i Pujol)
Doresca, Mariette Jean Coute (Hôpital Saint-Damien)
Sallés-Mingels, Beatriz (Institut Català de la Salut)
Canales-Aliaga, Lydia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Narcisse, Margareth (Department of Pediatrics, Division of Tuberculosis, Hôpital Saint-Damien, Nos Petits-Frères et Sœurs, Port-au-Prince 6112, Haiti; (J.G.); (M.J.C.D.); (M.N.))
Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Creswell, Jacob (Stop TB Partnership (Suïssa))
Cuevas, Luis E.. (Liverpool School of Tropical Medicine)
Domínguez, José (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. Fujifilm SILVAMP TB lipoarabinomannan (FujiLAM), a lateral-flow test to detect lipoarabinomannan in urine, is a novel non-sputum-based point-of-care diagnostic reported to have increased sensitivity for the diagnosis of TB among human immunodeficiency virus (HIV)-infected adults. We evaluate the performance of FujiLAM in children with presumptive TB. Fifty-nine children attending a paediatric hospital in Haiti with compatible signs and symptoms of TB were examined using Xpert MTB/RIF, smear microscopy and X-rays, and classified according to the certainty of diagnosis into bacteriologically confirmed TB (n = 5), unconfirmed TB (bacteriologically negative, n = 50) and unlikely TB (n = 4). Healthy children (n = 20) were enrolled as controls. FujiLAM sensitivity and specificity were 60% and 95% among children with confirmed TB. FujiLAM's high specificity and its characteristics as a point-of-care indicate the test has a good potential for the diagnosis of TB in children.
Ajuts:	Instituto de Salud Carlos III DTS18/0092 Instituto de Salud Carlos III FIS19/01408 European Commission. Horizon 2020 823854
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Tuberculosis ; Diagnosis ; Lipoarabinomannan ; LAM ; Children ; Urine ; Point-of-care
Publicat a:	Journal of clinical medicine, Vol. 10 (april 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10091914
PMID: 33925008

8 p, 268.4 KB

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