Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis : A Multicenter Matched Cohort Study
Escrihuela-Vidal, Francesc (Institut d'Investigació Biomèdica de Bellvitge)
López Cortés, Luis Eduardo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Escolà-Vergé, Laura (Hospital Universitari Vall d'Hebron)
Alarcón González, Arístides de (Instituto de Biomedicina de Sevilla)
Cuervo, Guillermo (Institut d'Investigació Biomèdica de Bellvitge)
Sánchez Porto, Antonio (Hospital Comarcal La Línea de la Concepción, Cádiz)
Fernández-Hidalgo, Nuria (Hospital Universitari Vall d'Hebron)
Luque, Rafael (Universidad de Sevilla)
Montejo, Miguel (Hospital Universitario de Cruces (Barakaldo, País Basc))
Miró, José M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Goenaga, Miguel Ángel (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Munoz, Patricia (Hospital General Universitario Gregorio Marañón)
Valerio, Maricela (Hospital General Universitario Gregorio Marañón)
Ripa, Marco (Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS))
Sousa-Regueiro, Dolores (Complejo Hospitalario Universitario de A Coruña)
Gurguí, Mercè (Institut d'Investigació Biomèdica Sant Pau)
Fariñas, Mª Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Mateu, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García Vázquez, Elisa (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Gálvez-Acebal, Juan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Carratalà, Jordi (Institut d'Investigació Biomèdica de Bellvitge)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Of 5336 consecutive cases of definite endocarditis, 72 (1. 4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88. 9%) cases and affected aortic native valve in 29 (40. 3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8. 3% vs 3. 5%, P = . 116); valve disorder, including perforation (22. 2% vs 18. 1%, P = . 584), pseudoaneurysm (16. 7% vs 8. 3%, P = . 108), or prosthesis dehiscence (1. 4% vs 6. 3%, P = . 170); paravalvular complications, including abscess (25% vs 18. 8%, P = . 264) and intracardiac fistula (5. 6% vs 3. 5%, P = . 485); heart failure (34. 7% vs 38. 9%, P = . 655); or embolic events (41. 7% vs 32. 6%, P = . 248). Indications for surgery (70. 8% vs 70. 8%; P = 1) and mortality (13. 9% vs 16. 7%; P = . 741) were similar between groups. SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG. In this multicenter matched cohort study, we found that Streptococcus anginosus group endocarditis follows a similar course to endocarditis caused by viridans or gallolyticus group streptococci, regarding valvular complications and prognostic variables such as indication for surgery and mortality.
Grants:	Ministerio de Economía y Competitividad RD16/0016/0005
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Infective endocarditis ; Streptococcus anginosus ; Viridans group streptococci ; Streptococcus gallolyticus
Published in:	Open Forum Infectious Diseases, Vol. 8 (march 2021) , ISSN 2328-8957

DOI: 10.1093/ofid/ofab163
PMID: 34189163

7 p, 167.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles