Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
Altet, Neus (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron)
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron)
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Milà, Celia (Hospital Universitari Vall d'Hebron)
Rodríguez-Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Godoy, Pere (Institut de Recerca Biomèdica de Lleida)
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron)
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo)
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2022
Abstract:	Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8. 7 (5. 9-12. 8)] and was a main factor related with LTBI [aOR (95% CI): 7. 57 (4. 79-11. 94)] and active TB [aOR (95% CI): 3. 40 (1. 45-7. 98)]. Moreover, IGRAs' sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response.
Grants:	Ministerio de Economía y Competitividad PI13/01546 Ministerio de Economía y Competitividad PI16/01912 Instituto de Salud Carlos III PI18/00411
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Mycobacterium tuberculosis ; Cigarette smoking ; Passive smoking ; Child ; Immunology
Published in:	Journal of clinical medicine, Vol. 11 (april 2022) , ISSN 2077-0383

DOI: 10.3390/jcm11072000
PMID: 35407608

12 p, 995.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles