Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
Caso, Javier R. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Macdowell, Karina S. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
González-Pinto, Ana (Universidad del País Vasco)
García, Saínza (Universidad del País Vasco)
Diego-Adeliño, Javier de (Institut d'Investigació Biomèdica Sant Pau)
Carceller-Sindreu, Mar (Institut d'Investigació Biomèdica Sant Pau)
Sarramea, F. (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Caballero-Villarraso, Javier (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Gracia-García, Patricia (Universidad de Zaragoza)
De-la-Cámara, Concepción (Universidad de Zaragoza)
Agüera, Luís F. (Hospital Universitario 12 de Octubre (Madrid))
Gòmez-Lus, María Luisa (Universidad Complutense de Madrid)
Alba, Claudio (Universidad Complutense de Madrid)
Rodríguez, Juan Miguel (Universidad Complutense de Madrid)
Leza, Juan Carlos (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Although alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD: Bilophila (2-fold) and Alistipes (1. 5-fold) were higher, while Anaerostipes (1. 5-fold) and Dialister (15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of Alistipes and Anaerostipes (1. 5-fold) and a complete depletion of Dialister compared with HC. Patients with r-MDD presented higher abundance of Bilophila (2. 5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group.
Ajuts:	Ministerio de Ciencia e Innovación FISPI13/01102 Agencia Estatal de Investigación SAF2016-75500-R Agencia Estatal de Investigación PID2019-109033RB-I00
Nota:	Altres ajuts: JdD-A was supported by the Catalan Intensification Programme (PERIS, SLT008/18/00092; Generalitat de Catalunya).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Depressive Disorder, Major ; Feces ; Female ; Gastrointestinal Microbiome ; Humans ; Immunity, Innate ; Male ; Microbiota
Publicat a:	Translational psychiatry, Vol. 11 Núm. 1 (december 2021) , p. 645, ISSN 2158-3188

DOI: 10.1038/s41398-021-01755-3
PMID: 34934041

10 p, 1.6 MB

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