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| Home > Articles > Published articles > Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment |
(Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Institut d'Investigació Biomèdica Sant Pau) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Universitat Internacional de Catalunya) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Universitat Internacional de Catalunya) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
| Date: | 2021 |
| Abstract: | Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. Objective: The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit. Methods: A total of 2,137 MCI patients were monitored over a 2. 4-year period. Four clusters of NPS (i. e. , Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitive trajectories using a comprehensive neuropsychological battery (NBACE) administered at baseline and at the three subsequent follow-ups. Results: A significant interaction between cluster and time in cognitive decline was found when verbal learning and cued-recall were explored (p = 0. 002 for both memory functions). For verbal learning, the Irritability cluster had the largest effect size (0. 69), whereas the Asymptomatic cluster showed the smallest effect size (0. 22). For cued-recall, the Irritability cluster had the largest effect size among groups (0. 64), and Anxiety/Depression had the smallest effect size (0. 21). Conclusions: In MCI patients, the Irritability and Apathy NPS clusters shared similar patterns of worsening in memory functioning, which could point to these NPS as risk factors of a faster cognitive decline, acting as early prognostic markers and helping in the diagnostic process. |
| Grants: | Agència de Gestió d'Ajuts Universitaris i de Recerca SGR17/001343 Instituto de Salud Carlos III PPII9/00335 Instituto de Salud Carlos III PI13/02434 Instituto de Salud Carlos III PI16/01861 Instituto de Salud Carlos III BA19/00020 Instituto de Salud Carlos III PI19/01301 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Anxiety ; Apathy ; Cognitive decline ; Depression ; Irritability ; Mild cognitive impairment ; Neuropsychiatric symptoms |
| Published in: | Frontiers in aging neuroscience, Vol. 13 (august 2021) , p. 718949, ISSN 1663-4365 |
