Impact of Dietary Supplementation with Sodium Butyrate Protected by Medium-Chain Fatty Acid Salts on Gut Health of Broiler Chickens
Sadurní, M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Barroeta, Ana Cristina (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Sala Pallarés, Roser (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Sol, Cinta (Norel)
Puyalto, Mónica (Norel)
Castillejos, Lorena (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data:	2022
Resum:	Nutritional strategies to improve gut health of broilers are under research. This study investigated the effect of dietary supplementation with sodium butyrate protected by sodium salts of medium-chain fatty acids as a feed additive on broiler gut health. The first experiment was conducted to evaluate the effect of supplementing at 0. 5, 1, and 2 kg/t in broilers housed under optimal conditions. Supplementation at 0. 5 and 1 kg/t maintained goblet cell counts at 10 days of age (p ≤ 0. 05), and supplementation at 1 kg/t decreased intraepithelial lymphocyte counts compared to 2 kg/t at 39 days (p ≤ 0. 10). Abdominal fat pad levels of lauric and myristic acids were gradually increased by supplement dose (p ≤ 0. 05). In the second experiment, the feed additive at 1 kg/t was evaluated in coccidiosis-challenged broilers. Experimental treatments were as follows: non-challenged, control-challenged, and supplemented-challenged treatments. Coccidiosis negatively impact performance and modify histomorphometry and microbiota (p ≤ 0. 05). The feed additive increased crypt depth at 7 days post-inoculation and goblet cell count at 14 days post-inoculation (p ≤ 0. 05). Further, supplementation interacted with the microbiota modification led by the coccidiosis (p ≤ 0. 05). These results suggest that this feed additive could be a useful strategy to reinforce the gut barrier, especially for birds under coccidiosis-challenge treatments.
Ajuts:	European Commission COMRDI16-1-0033
Nota:	This research was co-funded by the European Fund of Regional Development of the European Union within the framework of the FEDER operating program of Catalunya 2014-2020 (project COMRDI16-1-0033) and managed by ACCIÓ.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Animals, Vol. 12 Núm. 19 (october 2022) , p. 2496, ISSN 2076-2615

DOI: 10.3390/ani12192496
PMID: 36230237

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