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Página principal > Artículos > Artículos publicados > Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy |
Fecha: | 2022 |
Resumen: | This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk factors in subjects with type 1 (T1D) and type 2 (T2D) diabetes. This observational, cross-sectional substudy analyzed DR-related data from 309 T1D and 264 T2D subjects. The advanced lipoprotein and glycoprotein profile was determined by nuclear magnetic resonance (NMR) spectroscopy (Liposcale test). NMR analysis of lipoproteins revealed that T1D subjects with DR showed standard non-HDL particles, despite higher IDL lipid concentrations. Notably, IDL lipids were elevated in T1D subjects with worsened DR. VLDL and LDL were smaller, whereas HDL triglycerides were increased in DR compared with non-DR. On the other hand, the T2D subjects with DR showed altered characteristics in the LDL fraction, mainly revealed by a significant decrease in smaller LDL and a reduction in LDL-C. Moreover, the glycoprotein profile did not reveal significant changes among DR groups, regardless of the type of diabetes. However, lipoprotein characteristics and glycoproteins unveiled by NMR analysis did not improve the predictive value of conventional lipids or other traditional, well-established biomarkers of DR in our cohorts. |
Ayudas: | Ministerio de Sanidad y Consumo PI15/0625 Ministerio de Sanidad y Consumo PI17/01362 Ministerio de Sanidad y Consumo PI17/00232 Instituto de Salud Carlos III CB15/00071 Ministerio de Ciencia e Innovación CB15/00071 |
Nota: | Fundació La Marató de TV3 2016 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Diabetic retinopathy ; Lipoproteins ; Glycoproteins ; Triglycerides ; Remnants ; Nuclear magnetic resonance spectroscopy ; Type 1 diabetes ; Type 2 diabetes |
Publicado en: | Nutrients, Vol. 14 (september 2022) , ISSN 2072-6643 |
15 p, 4.5 MB |