Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy
Julve i Gil, Josep (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Rossell, Joana (Institut d'Investigació Biomèdica Sant Pau)
Correig Fraga, Eudald (Universitat Rovira i Virgili. Departament de Ciències Mèdiques Bàsiques)
Rojo López, Marina Idalia (Institut d'Investigació Biomèdica Sant Pau)
Amigó, Núria (Hospital Universitari Joan XXIII de Tarragona. Institut d'Investigació Sanitària Pere Virgili)
Hernández, Marta (Institut de Recerca Biomèdica de Lleida)
Traveset, Alicia (Institut de Recerca Biomèdica de Lleida)
Carbonell Puig, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Mauricio Puente, Dídac (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Castelblanco, Esmeralda (Endocrinology, Metabolism and Lipid Research Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA)

Date:	2022
Abstract:	This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk factors in subjects with type 1 (T1D) and type 2 (T2D) diabetes. This observational, cross-sectional substudy analyzed DR-related data from 309 T1D and 264 T2D subjects. The advanced lipoprotein and glycoprotein profile was determined by nuclear magnetic resonance (NMR) spectroscopy (Liposcale test). NMR analysis of lipoproteins revealed that T1D subjects with DR showed standard non-HDL particles, despite higher IDL lipid concentrations. Notably, IDL lipids were elevated in T1D subjects with worsened DR. VLDL and LDL were smaller, whereas HDL triglycerides were increased in DR compared with non-DR. On the other hand, the T2D subjects with DR showed altered characteristics in the LDL fraction, mainly revealed by a significant decrease in smaller LDL and a reduction in LDL-C. Moreover, the glycoprotein profile did not reveal significant changes among DR groups, regardless of the type of diabetes. However, lipoprotein characteristics and glycoproteins unveiled by NMR analysis did not improve the predictive value of conventional lipids or other traditional, well-established biomarkers of DR in our cohorts.
Grants:	Ministerio de Sanidad y Consumo PI15/0625 Ministerio de Sanidad y Consumo PI17/01362 Ministerio de Sanidad y Consumo PI17/00232 Instituto de Salud Carlos III CB15/00071 Ministerio de Ciencia e Innovación CB15/00071
Note:	Fundació La Marató de TV3 2016
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diabetic retinopathy ; Lipoproteins ; Glycoproteins ; Triglycerides ; Remnants ; Nuclear magnetic resonance spectroscopy ; Type 1 diabetes ; Type 2 diabetes
Published in:	Nutrients, Vol. 14 (september 2022) , ISSN 2072-6643

DOI: 10.3390/nu14193932
PMID: 36235586

15 p, 4.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles