Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis : Differences between males and females
Serra-Navarro, Maria (Biomedical Research Networking Center for Mental Health Network (CIBERSAM))
Amoretti, Silvia (Hospital Universitari Vall d'Hebron)
Verdolini, Norma (Local Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia)
Forte, Maria Florencia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Sánchez-Torres, Ana Maria (Instituto de Investigación Sanitaria de Navarra)
Vieta, Eduard (Centro de Investigación Biomédica en Red de Salud Mental)
Clougher, Derek (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Lobo, Antonio (Instituto de Investigación Sanitaria de Aragón)
González-Pinto, Ana (Department of Psychiatry, University of the Basque Country (UPV-EHU))
Panadero, Rocío (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Roldán, Alexandra (Institut d'Investigació Biomèdica Sant Pau)
Carvalho, André F. (Deakin University)
de la Serna, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Toll, Alba (Institut Hospital del Mar d'Investigacions Mèdiques)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Torrent, Carla (Biomedical Research Networking Center for Mental Health Network (CIBERSAM))
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra)
Bernardo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Data:	2022
Resum:	Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex differences are observed in individuals with psychosis in multiple domains. Nonetheless, few studies have explored the predictive factors of poor functioning according to sex in first-episode psychosis (FEP). This study aimed to explore sex differences, examine changes, and identify predictors of functioning according to sex after onset. The initial sample comprised 588 individuals. However, only adults with non-affective FEP (n = 247, 161 males and 86 females) and healthy controls (n = 224, 142 males and 82 females) were included. A comprehensive assessment including functional, neuropsychological, and clinical scales was performed at baseline and at 2-year follow-up. A linear regression model was used to determine the predictors of functioning at 2-year follow-up. FEP improved their functionality at follow-up (67. 4% of both males and females). In males, longer duration of untreated psychosis (β = 0. 328, p = 0. 003) and worse premorbid adjustment (β = 0. 256, p = 0. 023) were associated with impaired functioning at 2-year follow-up, while in females processing speed (β = 0. 403, p = 0. 003), executive function (β = 0. 299, p = 0. 020) and CR (β = −0. 307, p = 0. 012) were significantly associated with functioning. Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended.
Ajuts:	Instituto de Salud Carlos III PI20/00344
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	First episode non-affective psychosis ; Psychosocial functioning ; Sex differences ; Cognition ; Negative symptoms
Publicat a:	Frontiers in psychiatry, Vol. 13 (October 2022) , ISSN 1664-0640

DOI: 10.3389/fpsyt.2022.982583
PMID: 36339856

15 p, 987.6 KB

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