Drosophila melanogaster as a model to study innate immune memory
Arch Sisquella, Marta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vidal Ramos, Maria (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Koiffman, Romina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Melkie, Solomon Tibebu (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date:	2022
Abstract:	Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, Drosophila melanogaster. This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.
Grants:	"la Caixa" Foundation 10290002 Instituto de Salud Carlos III PI17/01511
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Drosophila melanogaster ; Innate immune memory ; Trained immunity ; Tolerance ; Resistance ; Infection
Published in:	Frontiers in microbiology, Vol. 13 (October 2022) , art. 991678, ISSN 1664-302X

DOI: 10.3389/fmicb.2022.991678
PMID: 36338030

20 p, 3.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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Articles > Published articles