Body weight of newborn and suckling piglets affects their intestinal gene expression
Villagómez Estrada, Sandra (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Pérez Hernández, José Francisco (Universitat de Barcelona. Departament de Bioquímica i Fisiologia)
Melo Duran, Diego Alexander (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
González Solé, Francesc (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
D'angelo, Matilde (Universitat Autònoma de Barcelona. Servei de Nutrició i Benestar Animal)
Pérez Hernández, José Francisco (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Solà Oriol, David (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data:	2022
Resum:	Modern hyperprolific sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0. 05) but also a tendency for a higher mRNA expression of GBP1 (inflammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0. 10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-inflammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0. 05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates. At birth and during lactation phase, the light body weight of piglets born from hyperprolific sows predisposed to a higher expression of stress and pro-inflammatory genes.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Birthweight ; Gene expression ; Hyperprolific sows ; Neonatal pigs ; Suckling pigs
Publicat a:	Journal of animal science, Vol. 100 (may 2022) , ISSN 1525-3163

DOI: 10.1093/jas/skac161
PMID: 35511683

8 p, 536.9 KB

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