Association of the kdigo risk classification with the prevalence of heart failure in patients with type 2 diabetes
Gimeno-Orna, José Antonio (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Rodríguez-Padial, Luis (Complejo Hospitalario de Toledo)
Anguita-Sánchez, Manuel (Instituto Maimónides de Investigación Biomédica de Córdoba)
Barrios, Vivencio (Hospital Universitario Ramón y Cajal (Madrid))
Muñiz, Javier (Coruña University. Cardiovascular Research Group. Health Sciences Department and Biomedic Research Institute de A Coruña (INIBIC). CIBERCV)
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The objectives of this study were to determine the main characteristics associated with the presence of heart failure (HF) in patients with type 2 diabetes (T2DM), and specifically to assess the association of the risk classification proposed by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines with HF. The DIABET-IC study is a multicentre, observational, prospective and analytical study in T2DM patients recruited in Spanish hospitals. This work, which features a cross-sectional design, has been conducted with the data obtained at the inclusion visit. The main dependent variable analysed was the presence of HF. The predictive variables evaluated were the demography, clinic, laboratory testing (including natriuretic peptides) and echocardiography. Patients were classified according to the number of vascular territories with atherosclerotic involvement and the KDIGO risk category. Multivariate logistic regression models were performed to determine the risk posed by the various baseline variables to present HF at the time of study inclusion. The study included 1517 patients from 58 hospitals, with a mean age of 67. 3 (standard deviation (SD): 10) years, out of which 33% were women. The mean DM duration was 14 (SD: 11) years. The prevalence of HF was 37%. In a multivariate analysis, the independent predictors of HF were in-creased age (odds ratio (OR) per 1 year = 1. 02; p = 0. 006), decreased systolic blood pressure (OR per 1 mmHg = 0. 98; p <0. 001), decreased haemoglobin (OR per 1 g/dL = 0. 86; p <0. 001), the presence of obstructive sleep apnoea (OR = 1. 61; p = 0. 006), the absence of hepatic steatosis (OR = 0. 59; p = 0. 016), the severity of atherosclerotic involvement (OR 1 territory = 1. 38 and OR.
Note:	Altres ajuts: Sociedad Española de Diabetes
Note:	Altres ajuts: Sociedad Española de Cardiología
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Type 2 diabetes ; Cardiovascular disease ; Heart failure ; KDIGO risk category
Published in:	Journal of clinical medicine, Vol. 10 Núm. 20 (october 2021) , p. 4634, ISSN 2077-0383

DOI: 10.3390/jcm10204634
PMID: 34682756

12 p, 863.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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