Genetic predisposition to alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
Ciampa, Iacopo (Hospital del Sagrat Cor (Barcelona, Catalunya))
Operto, Grégory (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable)
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Minguillon, Carolina (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable)
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Esteller, M. (Universitat de Barcelona)
Molinuevo, José Luis (Universitat Pompeu Fabra)
Guigó, Roderic (Barcelona Institute of Science and Technology (BIST))
Navarro, Arcadi 1969- (Universitat Pompeu Fabra)
Gispert, Juan Domingo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Vilor-Tejedor, Natalia (Erasmus University Medical Center Rotterdam)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0. 019; OR = 2. 564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-ε4 status (carriers vs. non-carriers), these results remained significant only for ε4 carriers (p value = 0. 011; OR = 1. 429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-892 Ministerio de Economía y Competitividad RYC-2013-13054 Ministerio de Ciencia e Innovación FJC2018-038085-I
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Genes, Vol. 12 Núm. 6 (june 2021) , p. 825, ISSN 2073-4425

DOI: 10.3390/genes12060825
PMID: 34072165

11 p, 1001.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Research articles
Articles > Published articles