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| Home > Articles > Published articles > The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis |
| Home > Articles > Published articles > The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis |
(Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) (Hospital Clínic i Provincial de Barcelona) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut d'Investigació Biomèdica Sant Pau) (Hospital Clínic i Provincial de Barcelona) (Institut de Química Avançada de Catalunya) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)| Date: | 2022 |
| Abstract: | Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely associated with arthritis, are contributors and sensors of inflammation through epigenetic modifications. In this study, we investigated associations between clinical features and DNA methylation in blood and synovial fluid (SF) MOs in a prospective cohort of patients with early inflammatory arthritis. DNA methylation profiles of undifferentiated arthritis (UA) blood MOs exhibited marked alterations in comparison with those from healthy donors. We identified additional differences both in blood and SF MOs after comparing patients with UA grouped by their future outcomes, i. e. , good versus poor. Patient profiles in subsequent visits revealed a reversion toward a healthy level in both groups, those requiring disease-modifying antirheumatic drugs and those who remitted spontaneously. Changes in disease activity between visits also affected DNA methylation, which was partially concomitant in the SF of UA and in blood MOs of patients with rheumatoid arthritis. Epigenetic similarities between arthritis types allow a common prediction of disease activity. Our results constitute a resource of DNA methylation-based biomarkers of poor prognosis, disease activity, and treatment efficacy for the personalized clinical management of early inflammatory arthritis. |
| Grants: | Instituto de Salud Carlos III PI17/00993 Agencia Estatal de Investigación SAF2017-88086-R Agencia Estatal de Investigación PID2020-117212RB-I00 Ministerio de Economía y Competitividad RD16/0012/0013 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Arthritis ; Autoimmunity ; Epigenetics ; Inflammation |
| Published in: | JCI Insight, Vol. 7 Núm. 9 (september 2022) , p. e158783, ISSN 2379-3708 |
