Impact of dietary lipids on the reverse cholesterol transport : What we learned from animal studies
Papotti, B. (Dipartimento di Scienze degli Alimenti e del Farmaco. Università di Parma)
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Potì, F. (Dipartimento di Medicina e Chirurgia. Unità di Neuroscienze. Università di Parma)
Zanotti, I. (Dipartimento di Scienze degli Alimenti e del Farmaco. Università di Parma)

Date:	2021
Abstract:	Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
Grants:	Instituto de Salud Carlos III CPII18/00004
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER) "Una manera de hacer Europa".
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Reverse cholesterol transport ; HDL ; Fatty acids ; Sterols ; Rodents
Published in:	Nutrients, Vol. 13 Núm. 8 (august 2021) , p. 2643, ISSN 2072-6643

DOI: 10.3390/nu13082643
PMID: 34444804

27 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles