Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease : An international overview
Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau)
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam)
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg)
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Arisi, Ivan (European Brain Research Institute (EBRI) "Rita Levi-Montalcini")
Amar, Elodie Bouaziz (GHU APHP Nord Lariboisière Fernand-Widal Hospital)
Beaume, Anne (CHU Poitiers)
Bedel, Aurelie (CHU Bordeaux)
Bellomo, Giovanni (University of Perugia)
Bigot-Corbel, Edith (CHU de Nantes)
Bjerke, Maria (University of Antwerp)
Blanc-Quintin, Marie-Céline (APHP Centre-Université de Paris, Cochin Hospital)
Boada, Mercè (Instituto de Salud Carlos III)
Bousiges, Olivier (Hôpitaux Universitaires de Strasbourg)
Chapman, Miles D (National Hospital for Neurology and Neurosurgery, UCL Queen Square)
DeMarco, Mari L. (University of British Columbia)
D'Onofrio, Mara (European Brain Research Institute (EBRI) "Rita Levi-Montalcini")
Dumurgier, Julien (GHU APHP Nord Lariboisière Fernand-Widal Hospital)
Dufour-Rainfray, Diane (CHU Tours)
Engelborghs, Sebastiaan (Center for Neurosciences and Department of Neurology)
Esselmann, Hermann (University Medical Center Goettingen (UMG)
Fogli, Anne (CHU Clermont-Ferrand)
Gabelle, Audrey (INSERM)
Galloni, Elisabetta (Dipartimento di Neuroscienze Divisione di Neurologia)
Gondolf, Clémentine (CHU Cote de Nacre Caen)
Grandhomme, Frédérique (CHU Cote de Nacre Caen)
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques)
Hart, Melanie (National Hospital for Neurology and Neurosurgery, UCL Queen Square)
Ikeuchi, Takeshi (Niigata University)
Jeromin, Andreas (Cohen Veterans Bioscience)
Kasuga, Kensaku (Niigata University)
Keshavan, Ashvini (UCL Institute of Neurology (Regne Unit))
Khalil, Michael (Medical University of Graz)
Körtvelyessy, Peter (German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité-Universitäts medizin Berlin)
Kulczynska-Przybik, Agnieszka (Medical University of Bialystok)
Laplanche, Jean-Louis (GHU APHP Nord Lariboisière Fernand-Widal Hospital)
Lewczuk, Piotr (Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg)
Li, Qiao-Xin (Florey Institute and The University of Melbourne)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Malaplate, Catherine (Biologie Moléculaire et Nutrition/ Université de Lorraine)
Marquié, Marta (Instituto de Salud Carlos III)
Masters, Colin L. (Florey Institute and The University of Melbourne)
Mroczko, Barbara (Medical University of Bialystok)
Nogueira, Léonor (CHU PURPAN)
Orellana, Adelina (Instituto de Salud Carlos III)
Otto, Markus (University of Ulm)
Oudart, Jean-Baptiste (Université de Reims Champagne-Ardenne)
Paquet, Claire (GHU APHP Nord Lariboisière Fernand-Widal Hospital)
Paoletti, Federico Paolini (University of Perugia)
Parnetti, Lucilla (University of Perugia)
Perret-Liaudet, Armand (Lyon University Hospital)
Peoc'h, Katell (Université de Paris GHU APHP Nord Beaujon Hospital)
Poesen, Koen (Leuven Brain Institute)
Puig-Pijoan, Albert (Institut Hospital del Mar d'Investigacions Mèdiques)
Quadrio, Isabelle (Lyon University Hospital)
Quillard-Muraine, Muriel (Normandie Univ)
Rucheton, Benoit (AP-HP Sorbonne University)
Schraen, Susanna (Université de Lille)
Schott, Jonathan M. (UCL Institute of Neurology (Regne Unit))
Shaw, Leslie M. (University of Pennsylvania)
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques)
Tsolaki, Magda (Aristotle University of Thessaloniki)
Tumani, Hayrettin (University of Ulm)
Udeh-Momoh, Chinedu T (Imperial College London)
Vaudran, Lucie (Univ. Lille)
Verbeek, Marcel M (Radboud University Medical Center)
Verde, Federico ("Dino Ferrari" Center, Università degli Studi di Milano)
Vermunt, Lisa (Vrije Universiteit Amsterdam)
Vogelgsang, Jonathan (Harvard Medical School)
Wiltfang, Jens (University of Aveiro)
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit))
Lehmann, Sylvain (Université de Montpellier)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
Grants:	Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI17/01474 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI19/00155
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; Cerebrospinal fluid biomarkers ; Clinical report ; Consensus approach ; Harmonization
Published in:	Alzheimer's & Dementia, Vol. 18 (december 2021) , p. 1868-1879, ISSN 1552-5279

DOI: 10.1002/alz.12545
PMID: 34936194

12 p, 312.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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