Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus
Rodríguez-Calvo, Ricardo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Granado-Casas, Minerva (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Pérez-Montes de Oca, Alejandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Rossell, Joana (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Masana, Luis (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Mauricio Puente, Dídac (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2023
Abstract:	Subjects with type 2 diabetes mellitus (T2D) are at increased risk for heart failure (HF). The cardiac-specific (FABP3) and adipose-tissue-specific (FABP4) types of the fatty acid binding proteins have been associated with both all-cause and cardiovascular (CV) mortality. The aim of this study was to explore the prognosis value of FABP3 and FABP4 in ambulatory subjects with chronic HF (CHF), with and without T2D. A prospective study involving 240 ambulatory CHF subjects was performed. Patients were followed-up for a mean of 5. 78 ± 3. 30 years and cause of death (if any) was recorded. Primary endpoints were defined as all-cause and CV death, and a composite endpoint that included CV death or hospitalization for HF was included as a secondary endpoint. Baseline serum samples were obtained and the serum FABP3 and FABP4 concentrations were assessed by sandwich enzyme-linked immunosorbent assay. Survival analysis was performed with multivariable Cox regressions, using Fine and Gray competing risks models when needed, to explore the prognostic value of FABP3 and FABP4 concentrations, adjusting for potential confounders. Type 2 diabetes mellitus was highly prevalent, accounting for 47. 5% for total subjects with CHF. Subjects with T2D showed higher mortality rates (T2D: 69. 30%; non-T2D: 50. 79%, p = 0. 004) and higher serum FABP3 (1829. 3 (1104. 9-3440. 5) pg/mL vs. 1396. 05 (820. 3-2362. 16) pg/mL, p = 0. 007) and FABP4 (45. 5 (27. 6-79. 8) ng/mL vs. 34. 1 (24. 09-55. 3) ng/mL, p = 0. 006) concentrations compared with non-T2D CHF subjects. In the whole study cohort, FABP3 was independently associated with all-cause death, and both FABP3 and FABP4 concentrations were associated with CV mortality. The predictive values of these two molecules for all-cause (FABP3: HR 1. 25, 95% CI 1. 09-1. 44; p = 0. 002. FABP4: HR 2. 21, 95% CI 1. 12-4. 36; p = 0. 023) and CV mortality (FABP3: HR 1. 28, 95% CI 1. 09-1. 50; p = 0. 002. FABP4: HR 4. 19, 95% CI 2. 21-7. 95; p < 0. 001) were only statistically significant in the subgroup of subjects with T2D. Notably, FABP4 (HR 2. 07, 95% CI 1. 11-3. 87; p = 0. 022), but not FABP3, also predicted the occurrence of the composite endpoint (death or hospitalization for HF) only in subjects with T2D. All these associations were not found in CHF subjects without T2D. Our findings support the usefulness of serum FABP3 and FABP4 concentrations as independent predictors for the occurrence of all-cause and CV mortality in ambulatory subjects with CHF with T2D.
Grants:	Instituto de Salud Carlos III PI17/01362 Instituto de Salud Carlos III PI17/00232 Ministerio de Economía y Competitividad CB15/00071 Ministerio de Sanidad y Consumo CB07/08/0028 Ministerio de Economía y Competitividad CB16/11/00403
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	All-cause death ; Cardiovascular death ; Chronic heart failure ; Diabetic patients ; FABP3 ; FABP4 ; Rehospitalization
Published in:	Antioxidants, Vol. 12 (march 2023) , ISSN 2076-3921

DOI: 10.3390/antiox12030645
PMID: 36978893

13 p, 983.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles