Author Correction : Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bolao, Ferran (Hospital Universitari de Bellvitge)
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Marchena, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández‑Prendes, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muñoz, Alvaro (Johns Hopkins University)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24. 7 kg/m2 [IQR, 21. 9-28. 4 kg/m2], eGFR was 105 mL/min/1. 73 m2 [IQR, 95. 7-113. 0 mL], 9. 7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4 > 3. 25). Prevalence of hyperuricemia was 12. 5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT ≤ 50, those with GGT between 51 and 300 U/L and those with GGT > 300 U/L were 4. 31 (95% CI 1. 62-11. 46) and 10. 3 (95% CI 3. 50-29. 90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Addiction ; Metabolic disorders
Publicat a:	Scientific reports, Vol. 13 (march 2023) , ISSN 2045-2322

Article original: https://ddd.uab.cat/record/253107?ln=es
DOI: 10.1038/s41598-023-31311-6
PMID: 36918703

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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