AmyloGraph : a comprehensive database of amyloid-amyloid interactions
Burdukiewicz, Michał (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Rafacz, Dominik (Warsaw University of Technology)
Barbach, Agnieszka (Wrocław University of Science and Technology)
Hubicka, Katarzyna (Wrocław University of Science and Technology)
Bąkała, Laura (Warsaw University of Technology)
Lassota, Anna (University of Birmingham)
Stecko, Jakub (Wrocław Medical University)
Szymańska, Natalia (Wrocław Medical University)
Wojciechowski, Jakub W. (Wrocław University of Science and Technology)
Kozakiewicz, Dominika (Hirszfeld Institute of Immunology and Experimental Therapy)
Szulc, Natalia (Wrocław University of Science and Technology)
Chilimoniuk, Jaroslaw (University of Wrocław)
Jęśkowiak, Izabela (Wroclaw Medical University)
Gąsior-Głogowska, Marlena (Wrocław University of Science and Technology)
Kotulska, Małgorzata (Wrocław University of Science and Technology)

Date:	2022
Abstract:	Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 experimentally studied interactions between 46 amyloid proteins or peptides. We also proposed a novel standardized terminology for the description of amyloid-amyloid interactions, which is included in our database, covering all currently known types of such a cross-talk, including inhibition of fibrillization, cross-seeding and other phenomena. The new approach allows for more specific studies on amyloids and their interactions, by providing very well-defined data. AmyloGraph, an online database presenting information on amyloid-amyloid interactions, is available at (). Its functionalities are also accessible as the R package (). AmyloGraph is the only publicly available repository for experimentally determined amyloid-amyloid interactions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Nucleic acids research, Vol. 51 (october 2022) , p. D352-D357, ISSN 1362-4962

DOI: 10.1093/nar/gkac882
PMID: 36243982

6 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles