Increased Presentation of Diabetic Ketoacidosis and Changes in Age and Month of Type 1 Diabetes at Onset during the COVID-19 Pandemic in Spain
Leiva-Gea, Isabel (Instituto de Investigación Biomédica de Málaga)
Antúnez Fernández, Cristina (Hospital Punta de Europa (Cadis, Andalusia))
Cardona-Hernandez, Roque (Hospital Sant Joan de Déu (Manresa))
Ferrer Lozano, Marta (Hospital Universitario Miguel Servet (Saragossa))
Bahíllo-Curieses, Pilar (Hospital Clínico Universitario de Valladolid)
Arroyo-Díez, Javier (Hospital Universitario Materno Infantil de Badajoz)
Clemente León, María (Hospital Universitari Vall d'Hebron)
Martín-Frías, Maria (Hospital Universitario Ramón y Cajal (Madrid))
Conde Barreiro, Santiago (Centro de Salud de Barbastro)
Mingorance Delgado, Andrés (Hospital General Universitario de Alicante (Alacant, País Valencià))
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	To assess the impact of the COVID-19 pandemic and lockdown measures on the presenting characteristics (age at diagnosis, severity, monthly distribution) of newly diagnosed type 1 diabetes in Spanish children. An ambispective observational multicenter study was conducted in nine Spanish tertiary-level hospitals between January 2015 and March 2021. Inclusion criteria: new cases of type 1 diabetes in children (0-14 years) recording age, sex, date of diagnosis, presence of diabetic ketoacidosis (DKA) at onset, and severity of DKA. Data were compared before and during the pandemic. We registered 1444 new cases of type 1 diabetes in children: 1085 in the pre-pandemic period (2015-2019) and 359 during the pandemic (2020-March 2021). There was a significant increase in the group aged ≤4 years in the pandemic period (chi-squared = 10. 986, df 2, p = 0. 0041). In 2020-2021, cases of DKA increased significantly by 12% (95% CI: 7. 2-20. 4%), with a higher percentage of moderate and severe DKA, although this increase was not significant. In 2020, there was a sharp decrease in the number of cases in March, with a progressive increase from May through November, higher than in the same months of the period 2015-2019, highlighting the increase in the number of cases in June, September, and November. The first three months of 2021 showed a different trend to that observed both in the years 2015-2019 and in 2020, with a marked increase in the number of cases. A change in monthly distribution was described, with an increase in DKA at onset of type 1 diabetes. No differences were found in severity, although there were differences in the age distribution, with an increase in the number of cases in children under 4 years of age.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Diabetes onset ; DKA ; Type 1 diabetes
Publicat a:	Journal of clinical medicine, Vol. 11 (july 2022) , ISSN 2077-0383

DOI: 10.3390/jcm11154338
PMID: 35893428

7 p, 1.3 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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