Characteristics of subjective cognitive decline associated with amyloid positivity
Janssen, Olin (Maastricht University. School for Mental Health and Neuroscience)
Jansen, W.J. (Maastricht University. School for Mental Health and Neuroscience)
Vos, S.J.B. (Maastricht University. School for Mental Health and Neuroscience)
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Parnetti, Lucilla (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia)
Gabryelewicz, T. (Department of Neurodegenerative Disorders. Mossakowski Medical Research Centre. Polish Academy of Sciences)
Fladby, T. (Department of Neurology. Akershus University Hospital)
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Villeneuve, S. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre)
Hort, J. (International Clinical Research Center. St. Anne's University Hospital)
Epelbaum, S. (Inserm Sorbonne Université. Inria. Aramis project-team. Paris Brain Institute - Institut du Cerveau (ICM))
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Engelborghs, Sebastiaan (Vrije Universiteit Brussel. (VUB) Brussels. and University of Antwerp)
van der Flier, W.M. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam)
Landau, S. (Helen Wills Neuroscience Institute. University of California)
Popp, J. (Old Age Psychiatry. University Hospital of Lausanne)
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg)
Scheltens, P. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam)
Rikkert, M.O. (Department of Geriatric Medicine. Radboud Alzheimer Center. Radboud University Medical Center)
Snyder, P.J. (Kingston. The University of Rhode Island)
Rowe, C. (Department of Molecular Imaging & Therapy. Austin Health)
Chételat, G.. (Institut National de la Santé et de la Recherche Médicale (Inserm))
Ruíz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Marquié, M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Chipi, E. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia)
Wolfsgruber, S. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn)
Heneka, M. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn)
Boecker, H. (Functional Neuroimaging Group. Department of Radiology. University Hospital Bonn)
Peters, O. (Charité - Universitätsmedizin Berlin)
Jarholm, J. (Department of Neurology. Akershus University Hospital)
Rami, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Tort-Merino, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Binette, A.P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre)
Poirier, J. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre)
Rosa-Neto, P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre)
Cerman, J. (International Clinical Research Center. St. Anne's University Hospital)
Dubois, B. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology)
Teichmann, M. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology)
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau)
Ebenau, J. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam)
Pocnet, C. (Old Age Psychiatry. University Hospital of Lausanne)
Eckerström, M. (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg)
Thompson, L. (Kingston. The University of Rhode Island)
Villemagne, V. (Department of Psychiatry. University of Pittsburgh)
Buckley, R. (righam and Women's Hospital (Boston, Estats Units d'Amèrica))
Burnham, S. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia)
Delarue, M. (Institut National de la Sant. et de la Recherche M.dicale (Inserm))
Freund-Levi, Yvonne (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet)
Wallin, Å.K. (Department of Clinical Sciences Malmö. Clinical Memory Research Unit. Lund University)
Ramakers, I. (Maastricht University. School for Mental Health and Neuroscience)
Tsolaki, Magda (George Papanicolaou General Hospital (Tessalònica, Grècia))
Soininen, H. (Institute of Clinical Medicine. Neurology. University of Eastern Finland)
Hampel, H. (GRC no 21. Alzheimer Precision Medicine (AMP). AP-HP. Pitié-Salpêtrière Hospital. Sorbonne University)
Spiru, L. (Geriatrics- Gerontology and Old Age Psychiatry. Alzheimer Unit. Ana Aslan International Foundation - Memory Center and Longevity Medicine)
Tijms, B. (Maastricht University. School for Mental Health and Neuroscience)
Ossenkoppele, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Verhey, F.R.J. (Maastricht University. School for Mental Health and Neuroscience)
Jessen, F. (German Center For Neurodegenerative Diseases/Clinical Research. Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE). Zentrum für klinische Forschung/AG)
Visser, P.J. (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet)

Data:	2022
Resum:	Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Ajuts:	Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI16/01861 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI19/01301 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III PI20/01330 Instituto de Salud Carlos III PI19/00745 Instituto de Salud Carlos III AC19/00103 European Commission. Horizon 2020 115975 European Commission. Horizon 2020 667696 European Commission JPco-fuND-2 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/125
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Amyloid ; Cerebrospinal fluid ; Positron emission tomography ; Subjective cognitive decline
Publicat a:	Alzheimer's & Dementia, Vol. 18 Núm. 10 (october 2022) , p. 1832-1845, ISSN 1552-5279

DOI: 10.1002/alz.12512
PMID: 34877782

14 p, 1.6 MB

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