Neuromodulatory effects and reproducibility of the most widely used repetitive transcranial magnetic stimulation protocols
Magnuson, Justine (University of British Columbia Okanagan)
Ozdemir, Mehmet A. (Izmir Katip Celebi University)
Mathieson, Elon (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Kirkman, Sofia (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Passera, Brice (Harvard Medical School)
Rampersad, Sumientra (Northeastern University)
Dufour, Alyssa B. (Hinda and Arthur Marcus Institute for Aging Research)
Brooks, Dana (Northeastern University)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Fried, Peter J. (Harvard Medical School)
Shafi, Mouhsin M. (Harvard Medical School)
Ozdemir, Recep A. (Harvard Medical School)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Repetitive transcranial magnetic stimulation (rTMS) is widely used in both research and clinical settings to modulate human brain function and behavior through the engagement of the mechanisms of plasticity. Based upon experiments using single-pulse TMS as a probe, the physiologic mechanism of these effects is often assumed to be via changes in cortical excitability, with 10 Hz rTMS increasing and 1 Hz rTMS decreasing the excitability of the stimulated region. However, the reliability and reproducibility of these rTMS protocols on cortical excitability across and within individual subjects, particularly in comparison to robust sham stimulation, have not been systematically examined. In a cohort of 28 subjects (39 ± 16 years), we report the first comprehensive study to (1) assess the neuromodulatory effects of traditional 1 Hz and 10 Hz rTMS on corticospinal excitability against both a robust sham control, and two other widely used patterned rTMS protocols (intermittent theta burst stimulation, iTBS; and continuous theta burst stimulation, cTBS), and (2) determine the reproducibility of all rTMS protocols across identical repeat sessions. At the group level, neither 1 Hz nor 10 Hz rTMS significantly modulated corticospinal excitability. 1 Hz and 10 Hz rTMS were also not significantly different from sham and both TBS protocols. Reproducibility was poor for all rTMS protocols except for sham. Importantly, none of the real rTMS and TBS protocols demonstrated greater neuromodulatory effects or reproducibility after controlling for potential experimental factors including baseline corticospinal excitability, TMS coil deviation and the number of individual MEP trials. These results call into question the effectiveness and reproducibility of widely used rTMS techniques for modulating corticospinal excitability, and suggest the need for a fundamental rethinking regarding the potential mechanisms by which rTMS affects brain function and behavior in humans.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 18 (june 2023) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0286465
PMID: 37352290

20 p, 2.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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