Marine Invertebrates : A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families
Pascual Alonso, Isel (University of Havana. Center for Protein Studies)
Almeida García, Fabiola (University of Havana. Center for Protein Studies)
Valdés Tresanco, Mario Ernesto (University of Calgary. Department of Biological Sciences)
Arrebola Sánchez, Yarini (University of Havana. Center for Protein Studies)
Ojeda del Sol, Daniel (University of Havana. Center for Protein Studies)
Sánchez Ramírez, Belinda (Centro de Inmunología Molecular)
Florent, Isabelle (Muséum National d'Histoire Naturelle)
Schmitt, Marjorie (Université de Strasbourg)
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Data:	2023
Resum:	Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes. They are also involved in several pathophysiological processes. Among peptidases, aminopeptidases catalyze the cleavage of the N-terminal amino acids of proteins or peptide substrates. They are distributed in many phyla and play critical roles in physiology and pathophysiology. Many of them are metallopeptidases belonging to the M1 and M17 families, among others. Some, such as M1 aminopeptidases N and A, thyrotropin-releasing hormone-degrading ectoenzyme, and M17 leucyl aminopeptidase, are targets for the development of therapeutic agents for human diseases, including cancer, hypertension, central nervous system disorders, inflammation, immune system disorders, skin pathologies, and infectious diseases, such as malaria. The relevance of aminopeptidases has driven the search and identification of potent and selective inhibitors as major tools to control proteolysis with an impact in biochemistry, biotechnology, and biomedicine. The present contribution focuses on marine invertebrate biodiversity as an important and promising source of inhibitors of metalloaminopeptidases from M1 and M17 families, with foreseen biomedical applications in human diseases. The results reviewed in the present contribution support and encourage further studies with inhibitors isolated from marine invertebrates in different biomedical models associated with the activity of these families of exopeptidases.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Aminopeptidase ; Aminopeptidase N ; Aminopeptidase A ; TRH-degrading ectoenzyme ; Leucyl aminopeptidase ; Enzyme inhibitors ; Drug-oriented inhibitors ; Marine invertebrates
Publicat a:	Marine drugs, Vol. 21, Issue 5 (April 2023) , art. 279, ISSN 1660-3397

DOI: 10.3390/md21050279
PMID: 37233473

37 p, 16.6 MB

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