Advanced lipoprotein profile disturbances in type 1 diabetes mellitus : A focus on LDL particles
Amor Fernández, Antonio J. (Hospital Clínic i Provincial de Barcelona)
Castelblanco, Esmeralda (Institut d'Investigació Biomèdica Sant Pau)
Hernández, Marta (Institut d'Investigació Biomédica de Lleida (IRB Lleida))
Giménez, Marga (Hospital Clínic i Provincial de Barcelona)
Granado-Casas, Minerva (Institut d'Investigació Biomèdica Sant Pau)
Blanco, Jesus (Hospital Clínic i Provincial de Barcelona)
Soldevila, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esmatjes Mompo, Enric (Hospital Clínic i Provincial de Barcelona)
Conget, Ignacio (Hospital Clínic i Provincial de Barcelona)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ortega, Emilio (Hospital Clínic i Provincial de Barcelona)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts. This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] spectroscopy) lipoprotein profiles were analysed. Crude and adjusted (by age, sex, statin use, body mass index and leukocyte count) comparisons were performed. The median (interquartile range) age of the study participants was 45 (38-53) years, 48. 2% were men. In the T1DM group, the median diabetes duration was 23 (16-31) years, and 8. 1% and 40. 2% of individuals had nephropathy and retinopathy, respectively. The proportion of participants with hypertension (29. 5 vs. 9. 2%), and statin use (45. 7% vs. 8. 1%) was higher in the T1DM vs. controls (p < 0. 001). The T1DM group had a better conventional (all parameters, p < 0. 001) and NMR-lipid profile than the control group. Thus, T1DM individuals showed lower concentrations of atherogenic lipoproteins (VLDL-particles and LDL-particles) and higher concentrations of anti-atherogenic lipoproteins (HDL-particles) vs. controls, even after adjusting for several confounders (p < 0. 001 for all). While non-diabetic women had a more favourable lipid profile than non-diabetic men, women with T1DM had a similar concentration of LDL-particles compared to men with T1DM (1231 [1125-1383] vs. 1257 [1128-1383] nmol/L, p = 0. 849), and a similar concentration of small-LDL-particles to non-diabetic women (672. 8 [614. 2-733. 9] vs. 671. 2 [593. 5-761. 4] nmol/L, respectively; p = 0. 790). Finally, T1DM individuals showed higher discrepancies between NMR-LDL-particles and conventional LDL-cholesterol than non-diabetic subjects (prevalence of LDL-cholesterol < 100 mg/dL & LDL-particles > 1000 nmol/L: 38 vs. 21. 2%; p < 0. 001). All these differences were largely unchanged in participants without lipid-lowering drugs (T1DM, n = 275; controls, n = 317). Overall, T1DM participants showed a more favourable conventional and NMR-lipid profile than controls. However, the NMR-assessment identified several lipoprotein derangements in LDL-particles among the T1DM population (higher discrepancies in NMR-LDL-particles vs. conventional LDL-cholesterol; a worse profile in T1DM women) that were overlooked in the conventional analysis. Further studies are needed to elucidate their role in the development of CVD in this population.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Advanced lipoprotein profile ; LDL-particles ; Lipoproteins ; Nuclear magnetic resonance spectroscopy ; Type 1 diabetes
Published in:	Cardiovascular diabetology, Vol. 19 Núm. 1 (september 2020) , p. 126, ISSN 1475-2840

DOI: 10.1186/s12933-020-01099-0
PMID: 32772924

16 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles