What is plan quality in radiotherapy? The importance of evaluating dose metrics, complexity, and robustness of treatment plans
Hernandez Masgrau, Victor (Hospital Universitari Sant Joan de Reus (Tarragona))
Hansen, Christian Rønn (Aarhus University Hospital (Aarhus, Dinamarca))
Widesott, Lamberto (Centro di protonterapia)
Bäck, Anna (Sahlgrenska Academy at the University of Gothenburg)
Canters, Richard (Maastricht University Medical Centre+)
Fusella, Marco (Veneto Institute of Oncology IOV - IRCCS)
Götstedt, Julia (University of Gothenburg)
Jurado-Bruggeman, Diego (Institut Català d'Oncologia)
Mukumoto, Nobutaka (Kyoto University)
Kaplan, Laura Patricia (Aarhus University Hospital (Aarhus, Dinamarca))
Koniarova, Irena (National Radiation Protection Institute)
Piotrowski, Tomasz (Greater Poland Cancer Centre)
Placidi, Lorenzo (Fondazione Policlinico Universitario "A. Gemelli" IRCCS)
Vaniqui, Ana (Maastricht University Medical Centre+)
Jornet, Nuria (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Plan evaluation is a key step in the radiotherapy treatment workflow. Central to this step is the assessment of treatment plan quality. Hence, it is important to agree on what we mean by plan quality and to be fully aware of which parameters it depends on. We understand plan quality in radiotherapy as the clinical suitability of the delivered dose distribution that can be realistically expected from a treatment plan. Plan quality is commonly assessed by evaluating the dose distribution calculated by the treatment planning system (TPS). Evaluating the 3D dose distribution is not easy, however; it is hard to fully evaluate its spatial characteristics and we still lack the knowledge for personalising the prediction of the clinical outcome based on individual patient characteristics. This advocates for standardisation and systematic collection of clinical data and outcomes after radiotherapy. Additionally, the calculated dose distribution is not exactly the dose delivered to the patient due to uncertainties in the dose calculation and the treatment delivery, including variations in the patient set-up and anatomy. Consequently, plan quality also depends on the robustness and complexity of the treatment plan. We believe that future work and consensus on the best metrics for quality indices are required. Better tools are needed in TPSs for the evaluation of dose distributions, for the robust evaluation and optimisation of treatment plans, and for controlling and reporting plan complexity. Implementation of such tools and a better understanding of these concepts will facilitate the handling of these characteristics in clinical practice and be helpful to increase the overall quality of treatment plans in radiotherapy.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Complexity ; Complexity metrics ; Dose metrics ; Plan quality ; Robust evaluation ; Robust optimisation ; Robustness
Publicat a:	Radiotherapy and oncology, Vol. 153 (december 2020) , p. 26-33, ISSN 1879-0887

DOI: 10.1016/j.radonc.2020.09.038
PMID: 32987045

8 p, 359.9 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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