Assessment of the psychosocial and economic impact according to sex in non-small cell lung cancer patients : an exploratory longitudinal study
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona)
Garcia-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña)
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Gonzalez-Larriba, José Luis (Hospital Clínico San Carlos (Madrid))
Coves, Juan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
De-Castro, Javier (Hospital Universitario La Paz (Madrid))
Domine, Manuel (Hospital Universitario Fundación Jiménez Díaz)
Lianes, Piar (Hospital de Mataró. Consorci Sanitari del Maresme)
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa))
Remon, Jordi (CIOCC Barcelona - HM Delfos)
Felip, Enriqueta (Hospital Universitari Vall d'Hebron)
Garrido, Pilar (Hospital Universitario Ramón y Cajal (Madrid))
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Little is known about the impact of sex on lung cancer patients from the psychological, economic and social perspectives. This study was designed to explore the psychosocial and economic impact according to sex of metastatic non-small cell lung cancer (mNSCLC) in patients and caregivers. Exploratory study of two cohorts of patients starting first-line treatment for mNSCLC. The following questionnaires were administered at baseline, 4 months later and following the first and second disease progression: APGAR, relationship impact scale, DUKE-UNC scale, economic impact in patients and caregiver, and Zarit scale. It was planned to include 1250 patients to get an 80% possibility of detecting as significant (p < 0. 05) effect sizes less than 0. 19 between men and women. Univariate comparisons were made between the tests applied to men and women. Overall survival was estimated with Kaplan-Meier method. Cox analyses were done to estimate hazard ratios (HRs) with 95% CI. 333 patients were included. Most families reported to continue being functional despite the lung cancer diagnosis. Regardless of sex, they did not perceive changes in their partner relationship. Most patients felt their social support was normal. Roughly 25% of people reported a worsening in their economic situation, without remarkable differences by sex. Statistically significant differences were found between both groups regarding the caregiver's relationship to the patient (more parents were the caregiver in females than in males, p < 0. 0001) and the caregiver's employment situation (more employed caregivers in females) (p < 0. 0001). Most caregivers of both sexes considered that taking care of their relative did not pose a significant burden. This study provides a preliminary insight into sex-related characteristics in the management of advanced NSCLC and its impact on the emotional, social and economic burden of patients and their caregivers, and recall the high priority of researching in cancer from a sex perspective. Nevertheless, due to the low recruitment rate and the relevant loss of patients during the follow-up, it was difficult to find differences by sex. Trial registration: ClinicalTrials. gov identifier: NCT02336061. Ethics committee: Comité Ético de Investigación Clínica del Hospital Clínic de Barcelona, Spain. Reference number: HCB/2014/0705.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Carcinoma ; Caregivers ; Non-small-cell lung ; Sex characteristics
Publicat a:	BMC Psychology, Vol. 8 Núm. 1 (december 2020) , p. 123, ISSN 2050-7283

DOI: 10.1186/s40359-020-00489-z
PMID: 33228796

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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