High adherence to the nordic diet is associated with lower levels of total and platelet-derived circulating microvesicles in a norwegian population
Chiva-Blanch, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Laake, Kristian (University of Oslo)
Myhre, Peder (University of Oslo)
Bratseth, Vibeke (University of Oslo)
Arnesen, Harald (University of Oslo)
Solheim, Svein (Oslo University Hospital Ullevål)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Seljeflot, Ingebjorg (University of Oslo)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Circulating microvesicles (cMV) are small phospholipid-rich blebs shed from the membrane of activated vascular cells that contribute to vascular disease progression. We aimed to investigate whether the quality of the Nordic diet is associated with the degree of blood and vascular cell activation measured by MV shedding in elderly patients after an acute myocardial infarction (AMI). One-hundred and seventy-four patients aged 70-82 years were included in this cross-sectional study. Fasting blood samples were taken within 2 to 8 weeks after an AMI. Annexin V (AV) cMV derived from blood and vascular cells were measured through flow cytometry. A patient's usual diet was recorded with the SmartDiet® questionnaire. Patients with higher adherence to the Nordic diet (highest diet score) had lower levels of total AV and platelet-derived (CD61/AV and CD31/AV) cMV. Dietary habits influence cellular activation. A high adherence to the Nordic diet (assessed by the SmartDiet® score) in elderly post-AMI patients was associated with lower levels of platelet activation, which was reflected by a lesser release of MV carrying platelet-derived epitopes, potentially contributing to an explanation of the cardioprotective effects of the Nordic diet.
Ajuts:	Ministerio de Economía y Competitividad IJCI-2015-26358
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cardiovascular disease ; Circulating microvesicles ; Nordic diet ; Platelets ; SmartDiet
Publicat a:	Nutrients, Vol. 11 Núm. 5 (may 2019) , p. 1114, ISSN 2072-6643

DOI: 10.3390/nu11051114
PMID: 31109111

12 p, 1.4 MB

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