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| Home > Articles > Published articles > A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes : |
(Institut d'Investigació Biomèdica Sant Pau) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Hospital Universitari Sant Joan de Reus (Tarragona)) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Sanitària Pere Virgili) (Hospital Clínic i Provincial de Barcelona) (Institut Hospital del Mar d'Investigacions Mèdiques) (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) (Institut Hospital del Mar d'Investigacions Mèdiques)| Date: | 2019 |
| Abstract: | The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0. 041 and P = 0. 053, versus baseline and the control intervention, respectively), CAV1 (P = 0. 070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0. 005, P = 0. 005, and P = 0. 038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes. |
| Grants: | Ministerio de Ciencia e Innovación AGL2009-13517-C03-01 Ministerio de Economía y Competitividad AGL2012-40144-C03-01 Ministerio de Sanidad y Consumo CB06/03/0028 Instituto de Salud Carlos III CB07/08/0016 Instituto de Salud Carlos III CD17/00122 Instituto de Salud Carlos III CD17/00233 Instituto de Salud Carlos III JR17/00022 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | HDL cholesterol ; Cholesterol efflux ; Functional virgin olive oil ; Olive oil phenolic compounds ; Thyme phenolic compounds ; Transcriptomics |
| Published in: | Nutrients, Vol. 11 Núm. 8 (2019) , p. 1732, ISSN 2072-6643 |
