Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors : role of immunosuppresors and failure of antiretrovirals
Roc, Lourdes (Hospital Universitario Miguel Servet (Saragossa))
De Mendoza, Carmen (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Fernández-Alonso, Mirian (Clinica Universitaria (Pamplona))
Reina, Gabriel (Clinica Universitaria (Pamplona))
Soriano, Vicente (Universidad Internacional de La Rioja. Facultad de Ciencias de la Salud)
Caballero Requero, Estrella (Hospital Universitari Vall d'Hebron)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)
Manzardo, Christian (Hospital Clínic i Provincial de Barcelona)
Miró, Josep M. (Hospital Clínic i Provincial de Barcelona)
Escudero, Domingo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Niubó, Jordi (Hospital Universitari de Bellvitge)
Margall, Núria (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HTLV-1 ; Antiretroviral drugs ; Myelopathy ; Screening ; Transplantation
Published in:	Therapeutic Advances in Infectious Disease, Vol. 6 (2019) , p. 1-8, ISSN 2049-937X

DOI: 10.1177/2049936119868028
PMID: 31467675

8 p, 615.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles