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| Home > Articles > Published articles > Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice |
| Home > Articles > Published articles > Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice |
(Universidad Nacional de Entre Ríos. Facultad de Ciencias de la Alimentación) (Institut d'Investigació Biomèdica Sant Pau) (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)| Date: | 2019 |
| Abstract: | Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A-stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities. |
| Grants: | Agencia Estatal de Investigación AGL2017-82417-R Agencia Estatal de Investigación AGL2016-75329-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-683 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-196 |
| Note: | Altres ajuts: Associació Catalana de la Diabetis (600004 - Ajut ACD a la recerca en diabetis 2017); Instituto de Salud Carlos III; Ministerio de Ciencia, Innovación y Universidades (CIBEROBN-AEI/FEDER, UE); Conicyt's fellowship from the Government of Chile; Conacyt's fellowship from the Government of México; BEC.AR fellowship from Ministerio de Educación, Cultura, Ciencia y Tecnología, Argentina. |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Anthocyanins ; Browning ; Carbohydrate-responsive element binding protein b ; Delphinidin ; Fibroblast growth factor 21 ; High-fat diet ; Maqui berry ; White adipose tissue |
| Published in: | Antioxidants, Vol. 8 Núm. 9 (september 2019) , p. 360, ISSN 2076-3921 |
