Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals : Examining the Necessity to Adjust for Biomarker Status in Normative Data
Bos, Isabelle (Maastricht University)
Vos, Stephanie J.B. (Maastricht University)
Jansen, Willemijn J. (Maastricht University)
Vandenberghe, Rik (KU Leuven)
Gabel, Silvy (KU Leuven)
Estanga, Ainara (CITA-Alzheimer Foundation)
Ecay-Torres, Mirian (CITA-Alzheimer Foundation)
Tomassen, Jori (Vrije Universiteit Amsterdam)
den Braber, Anouk (Vrije Universiteit Amsterdam)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Wallin, Anders (University of Gothenburg Sahlgrenska Academy)
Kettunen, Petronella (University of Oxford)
Molinuevo, José Luis (Universitat Pompeu Fabra)
Rami, Lorena (Hopsital Clínic Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS))
Chetelat, Gaël (Université de Caen-Normandie GIP Cyceron)
de la Sayette, Vincent (CHU de Caen)
Tsolaki, Magda (AHEPA University Hospital (Grècia))
Freund-Levi, Yvonne (Norrtälje Hospital Tiohundra)
Johannsen, Peter (University of Copenhagen)
Novak, Gerald P. (Janssen Pharmaceutical Research and Development)
Ramakers, Inez (Maastricht University)
Verhey, Frans R. (Maastricht University)
Visser, Pieter J. (Vrije Universiteit Amsterdam)
Universitat Autònoma de Barcelona

Data:	2018
Resum:	We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had Aβ status and neuropsychological data available. Linear mixed models were used to assess the associations of Aβ and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B). All test except the VFT were associated with Aβ status and this influence was augmented by age. We found no influence of tau on any of the cognitive tests. For the AVLT Immediate and Delayed recall and the TMT part A and B, we calculated norms in individuals without Aβ pathology (Aβ- norms), which we validated in an independent memory-clinic cohort by comparing their predictive accuracy to published norms. For memory tests, the Aβ- norms rightfully identified an additional group of individuals at risk of dementia. For non-memory test we found no difference. We confirmed the relationship between Aβ and cognition in cognitively normal individuals. The Aβ- norms for memory tests in combination with published norms improve prognostic accuracy of dementia.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Amyloid-beta ; Cognition ; Neuropsychological examination ; Normative data ; Tau
Publicat a:	Frontiers in aging neuroscience, Vol. 10 (25 2018) , p. 193, ISSN 1663-4365

DOI: 10.3389/fnagi.2018.00193
PMID: 29988624

11 p, 814.5 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats