An exploratory, large-scale study of pain and quality of life outcomes in cancer patients with moderate or severe pain, and variables predicting improvement
Maximiano, Constanza (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
López, Iker (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Martín-Lorente, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Zugazabeitia, Luis (Hospital Povisa (Vigo, Pontevedra))
Martí-Ciriquián, Juan L. (Hospital General Universitario de Alicante (Alacant, País Valencià))
Núñez, Miguel A. (Hospital Santa María Nai (Orense))
Contreras, Jorge (Hospital Regional Universitario de Málaga)
Herdman, Michael (Insight Consulting and Research)
Traseira, Susana (Mundipharma Pharmaceuticals S.L.)
Provencio Pulla, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2018
Resum:	There have been few large-scale, real world studies in Spain to assess change in pain and quality of life (QOL) outcomes in cancer patients with moderate to severe pain. This study aimed to assess changes on both outcomes after 3 months of usual care and to investigate factors associated with change in QoL. Large, multi-centre, observational study in patients with lung, head and neck, colorectal or breast cancer experiencing a first episode of moderate to severe pain while attending one of the participating centres. QoL was assessed using the EuroQol-5D questionnaire and pain using the Brief Pain Inventory (BPI). Instruments were administered at baseline and after 3 months of follow up. Multivariate analyses were used to assess the impact of treatment factors, demographic and clinical variables, pain and other symptoms on QoL scores. 1711 patients were included for analysis. After 3 months of usual care, a significant improvement was observed in pain and QoL in all four cancer groups (p<0. 001). Effect sizes were medium to large on the BPI and EQ-5D Index and Visual Analogue Scale (VAS). Improvements were seen on the majority of EQ-5D dimensions in all patient groups, though breast cancer patients showed the largest gains. Poorer baseline performance status (ECOG) and the presence of anxiety/depression were associated with significantly poorer QOL outcomes. Improvements in BPI pain scores were associated with improved QoL. In the four cancer types studied, pain and QoL outcomes improved considerably after 3 months of usual care. Improvements in pain made a substantial contribution to QoL gains whilst the presence of anxiety and depression and poor baseline performance status significantly constrained improvement.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 13 Núm. 4 (april 2018) , p. e0193233, ISSN 1932-6203

DOI: 10.1371/journal.pone.0193233
PMID: 29614068

14 p, 1019.0 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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