Web of Science: 58 cites, Scopus: 59 cites, Google Scholar: cites,
Microvesicles in Atherosclerosis and Angiogenesis : From Bench to Bedside and Reverse
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Suades, Rosa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau)
Chiva-Blanch, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data: 2017
Resum: Atherosclerosis (AT) is a progressive chronic disease involving lipid accumulation, fibrosis, and inflammation in medium and large-sized arteries, and it is the main cause of cardiovascular disease (CVD). AT is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Despite lipid-lowering drugs have shown to decrease the risk of cardiovascular events (CVEs), there is a significant burden of AT-related morbidity and mortality. Identification of subjects at increased risk for CVE as well as discovery of novel therapeutic targets for improved treatment strategies are still unmet clinical needs in CVD. Microvesicles (MVs), small extracellular plasma membrane particles shed by activated and apoptotic cells have been widely linked to the development of CVD. MVs from vascular and resident cells by facilitating exchange of biological information between neighboring cells serve as cellular effectors in the bloodstream and play a key role in all stages of disease progression. This article reviews the current knowledge on the role of MVs in AT and CVD. Attention is focused on novel aspects of MV-mediated regulatory mechanisms from endothelial dysfunction, vascular wall inflammation, oxidative stress, and apoptosis to coagulation and thrombosis in the progression and development of atherothrombosis. MV contribution to vascular remodeling is also discussed, with a particular emphasis on the effect of MVs on the crosstalk between endothelial cells and smooth muscle cells, and their role regulating the active process of AT-driven angiogenesis and neovascularization. This review also highlights the latest findings and main challenges on the potential prognostic, diagnostic, and therapeutic value of cell-derived MVs in CVD. In summary, MVs have emerged as new regulators of biological functions in atherothrombosis and might be instrumental in cardiovascular precision medicine; however, significant efforts are still needed to translate into clinics the latest findings on MV regulation and function.
Ajuts: Ministerio de Economía y Competitividad PI16/01915
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Ressenya ; recerca ; Versió publicada
Matèria: Angiogenesis ; Atherosclerosis ; Cardiovascular diseases ; Cell-derived microvesicles ; Endothelial dysfunction ; Inflammation ; Neovascularization ; Thrombosis
Publicat a: Frontiers in Cardiovascular Medicine, Vol. 4 (18 2017) , p. 77, ISSN 2297-055X

DOI: 10.3389/fcvm.2017.00077
PMID: 29326946


20 p, 2.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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 Registre creat el 2024-02-20, darrera modificació el 2024-04-26



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