Physical Activity and Sedentary Time in Pregnancy : An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
Zafaranieh, Saghi (University of Graz)
Dieberger, Anna Maria (Medical University of Graz)
Leopold-Posch, Barbara (Medical University of Graz)
Huppertz, Berthold (Medical University of Graz)
Granitzer, Sebastian (Medical University of Vienna)
Hengstschläger, Markus (Medical University of Vienna)
Gundacker, Claudia (Medical University of Vienna)
Desoye, Gernot (Medical University of Graz)
Van Poppel, Mireille (University of Graz)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Regular moderate-to-vigorous physical activity (MVPA) and reduced sedentary time (ST) improve maternal glucose metabolism in pregnancy. More MVPA and less ST outside pregnancy increase antioxidant capacity, hence, are beneficial in preventing oxidative stress. The placenta is the first line of defense for the fetus from an adverse maternal environment, including oxidative stress. However, effects of MVPA and ST on oxidative stress markers in the placenta are unknown. The purpose of this study was to assess the association of MVPA and ST in pregnancy with oxidative stress markers in placentas of overweight/obese women (BMI ≥ 29 kg/m). MVPA and ST were objectively measured with accelerometers at <20 weeks, 24-27 and 35-37 weeks of gestation. Using linear Bayesian multilevel models, the associations of MVPA and ST (mean and changes) with mRNA expression of a panel of 11 oxidative stress related markers were assessed in 96 women. MVPA was negatively correlated with HSP70 mRNA expression in a sex-independent manner and with GCLM expression only in placentas of female fetuses. ST was positively associated with HO-1 mRNA expression in placentas of male neonates. None of the other markers were associated with MVPA or ST. We speculate that increasing MVPA and reducing ST attenuates the oxidative stress state in placentas of obese pregnant women.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Obesity ; Oxidative stress ; Physical activity ; Placenta ; Sedentary behavior
Published in:	Biomedicines, Vol. 10 Núm. 5 (may 2022) , p. 1069, ISSN 2227-9059

DOI: 10.3390/biomedicines10051069
PMID: 35625806

13 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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