Eosinophils in the Gastrointestinal Tract : Key Contributors to Neuro-Immune Crosstalk and Potential Implications in Disorders of Brain-Gut Interaction
Salvo-Romero, Eloísa (Universitat Autònoma de Barcelona. Facultat de Medicina)
Rodiño-Janeiro, Bruno K. (Vall d'Hebron Institut de Recerca (VHIR))
Albert-Bayo, Mercé (Universitat Autònoma de Barcelona. Facultat de Medicina)
Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron)
Santos, Javier (Universitat Autònoma de Barcelona. Facultat de Medicina)
Farré, Ricard (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Madrid))
Martínez, Cristina (Instituto de Investigación Biomédica de Lleida Fundación Dr. Pifarré (Lleida))
Vicario Perez, Maria (Vall d'Hebron Institut de Recerca (VHIR))

Data:	2022
Resum:	Eosinophils are innate immune granulocytes actively involved in defensive responses and in local and systemic inflammatory processes. Beyond these effector roles, eosinophils are fundamental to maintaining homeostasis in the tissues they reside. Gastrointestinal eosinophils modulate barrier function and mucosal immunity and promote tissue development through their direct communication with almost every cellular component. This is possible thanks to the variety of receptors they express and the bioactive molecules they store and release, including cytotoxic proteins, cytokines, growth factors, and neuropeptides and neurotrophines. A growing body of evidence points to the eosinophil as a key neuro-immune player in the regulation of gastrointestinal function, with potential implications in pathophysiological processes. Eosinophil-neuron interactions are facilitated by chemotaxis and adhesion molecules, and the mediators released may have excitatory or inhibitory effects on each cell type, with physiological consequences dependent on the type of innervation involved. Of special interest are the disorders of the brain-gut interaction (DBGIs), mainly functional dyspepsia (FD) and irritable bowel syndrome (IBS), in which mucosal eosinophilia and eosinophil activation have been identified. In this review, we summarize the main roles of gastrointestinal eosinophils in supporting gut homeostasis and the evidence available on eosinophil-neuron interactions to bring new insights that support the fundamental role of this neuro-immune crosstalk in maintaining gut health and contributing to the pathophysiology of DBGIs.
Ajuts:	Ministerio de Economía y Competitividad FI12/00254 Ministerio de Economía y Competitividad CD15/00010 Ministerio de Economía y Competitividad FI20/00256 Instituto de Salud Carlos III PI19/01643 Ministerio de Economía y Competitividad PI17/0190 Ministerio de Economía y Competitividad CP18/00116 Ministerio de Economía y Competitividad CPII16/00031 Ministerio de Sanidad y Consumo CB06/04/0021
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Intestinal eosinophils ; Neuro-immune interaction ; Disorders of brain-gut interaction
Publicat a:	Cells, Vol. 11 (may 2022) , ISSN 2073-4409

DOI: 10.3390/cells11101644
PMID: 35626681

18 p, 2.1 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats