Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Argyelan, Miklos (The Zucker Hillside Hospital)
Deng, Zhi-De (Duke University School of Medicine)
Ousdal, Olga Therese (Haukeland University Hospital (Bergen, Noruega))
Oltedal, Leif (Haukeland University Hospital (Bergen, Noruega))
Angulo, Brian (Feinstein Institutes for Medical Research)
Baradits, Mate (Semmelweis University)
Spitzberg, Andrew J. (The Zucker Hillside Hospital)
Kessler, Ute (University of Bergen)
Sartorius, Alexander (University of Heidelberg)
Dols, Annemiek (Vrije Universiteit Amsterdam)
Narr, Katherine L. (University of California Los Angeles)
Espinoza, Randall (University of California Los Angeles)
van Waarde, Jeroen A. (Rijnstate)
Tendolkar, Indira (Donders Institute for Brain)
van Eijndhoven, Philip (Donders Institute for Brain, Cognition and Behavior)
van Wingen, Guido (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos). Amsterdam Neuroscience)
Takamiya, Akihiro (Leuven Brain Institute)
Kishimoto, Taishiro (Keio University School of Medicine)
Jorgensen, Martin Balslev (University of Copenhagen)
Jorgensen, Anders (University of Copenhagen)
Paulson, Olaf B. (University of Copenhagen)
Yrondi, Antoine (Univerité de Toulouse)
Péran, Patrice (Univeristé de Toulouse)
Soriano-Mas, Carles (Institut d'Investigació Biomèdica de Bellvitge)
Cardoner, Narcís (Institut d'Investigació Biomèdica Sant Pau)
Cano, Marta (Institut d'Investigació Biomèdica Sant Pau)
van Diermen, Linda (Psychiatric Center Bethanie)
Schrijvers, Didier (University Psychiatric Center Duffel)
Belge, Jean-Baptiste (Radboud University Medical Centre)
Emsell, Louise (University Psychiatric Center-KU Leuven)
Bouckaert, Filip (University Psychiatric Center-KU Leuven)
Vandenbulcke, Mathieu (University Psychiatric Center-KU Leuven)
Kiebs, Maximilian (University Hospital Bonn (Bonn, Alemanya))
Hurlemann, René (School of Medicine & Health Sciences University Hospital Oldenburg)
Mulders, Peter CR. (Donders Institute for Brain, Cognition and Behavior)
Redlich, Ronny (German Center for Mental Health (DZPG))
Dannlowski, Udo (University of Muenster)
Kavakbasi, Erhan (University of Muenster)
Kritzer, Michael D. (Massachusetts General Hospital (Boston))
Ellard, Kristen K. (Massachusetts General Hospital (Boston))
Camprodon, Joan Albert (Massachusetts General Hospital (Boston))
Petrides, Georgios (The Zucker Hillside Hospital)
Malhotra, Anil K. (The Zucker Hillside Hospital)
Abbott, Christopher (University of New Mexico)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0. 65, 0. 58, 0. 40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2. 35, p = 0. 019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Depression ; Predictive markers
Publicat a:	Molecular psychiatry, Vol. 29 (november 2023) , p. 229-237, ISSN 1476-5578

Correction: https://ddd.uab.cat/record/293136
DOI: 10.1038/s41380-023-02318-2
PMID: 37985787

9 p, 2.2 MB

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